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Penicillin and Cefotaxime Resistance of Quinolone-Resistant Neisseria meningitidis Clonal Complex 4821, Shanghai, China, 1965-2020.
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- المؤلفون: Chen M; Shao Y; Luo J; Yuan L; Wang M; Chen M; Guo Q
- المصدر:
Emerging infectious diseases [Emerg Infect Dis] 2023 Feb; Vol. 29 (2), pp. 341-350.
- نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
- بيانات النشر:
Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
- الموضوع:
- نبذة مختصرة :
Clonal complex 4821 (CC4821) Neisseria meningitidis, usually resistant to quinolones but susceptible to penicillin and third-generation cephalosporins, is increasing worldwide. To characterize the penicillin-nonsusceptible (Pen NS ) meningococci, we analyzed 491 meningococci and 724 commensal Neisseria isolates in Shanghai, China, during 1965-2020. The Pen NS proportion increased from 0.3% in 1965-1985 to 7.0% in 2005-2014 and to 33.3% in 2015-2020. Of the 26 Pen NS meningococci, 11 (42.3%) belonged to the CC4821 cluster; all possessed mutations in penicillin-binding protein 2, mostly from commensal Neisseria. Genetic analyses and transformation identified potential donors of 6 penA alleles. Three Pen NS meningococci were resistant to cefotaxime, 2 within the CC4821 cluster. With 96% of the Pen NS meningococci beyond the coverage of scheduled vaccination and the cefotaxime-resistant isolates all from toddlers, quinolone-resistant CC4821 has acquired penicillin and cefotaxime resistance closely related to the internationally disseminated ceftriaxone-resistant gonococcal FC428 clone, posing a greater threat especially to young children.
- References:
Antimicrob Agents Chemother. 2007 Aug;51(8):2784-92. (PMID: 17517841)
Clin Infect Dis. 2021 Oct 5;73(7):1185-1193. (PMID: 33900407)
J Antimicrob Chemother. 2019 Jul 1;74(7):1812-1819. (PMID: 31002306)
Pediatr Infect Dis J. 2004 Dec;23(12 Suppl):S274-9. (PMID: 15597069)
Lancet Infect Dis. 2014 Sep;14(9):805-12. (PMID: 25104306)
Lancet. 2006 Feb 4;367(9508):419-23. (PMID: 16458767)
Virus Evol. 2015 May 26;1(1):vev003. (PMID: 27774277)
Front Microbiol. 2022 Jan 24;12:801196. (PMID: 35140696)
PLoS Med. 2015 Jun 09;12(6):e1001838; discussion e1001838. (PMID: 26057853)
PLoS One. 2020 Dec 10;15(12):e0243426. (PMID: 33301524)
PLoS One. 2021 Nov 29;16(11):e0260677. (PMID: 34843604)
Diagn Microbiol Infect Dis. 2001 Sep-Oct;41(1-2):83-8. (PMID: 11687319)
Antimicrob Agents Chemother. 2020 Jan 27;64(2):. (PMID: 31740556)
FEMS Microbiol Rev. 2007 Jan;31(1):71-83. (PMID: 17233636)
J Clin Microbiol. 2017 May;55(5):1454-1468. (PMID: 28228492)
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3140-5. (PMID: 9501229)
Sci Rep. 2018 Aug 17;8(1):12334. (PMID: 30120257)
Vaccine. 2015 Feb 18;33(8):1092-7. (PMID: 25444796)
Commun Dis Intell (2018). 2021 Aug 30;45:. (PMID: 34496732)
PLoS One. 2020 Nov 12;15(11):e0241989. (PMID: 33180804)
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4339-41. (PMID: 27067334)
Emerg Infect Dis. 2017 Aug;23(8):1364-1367. (PMID: 28609259)
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Feb 6;55(2):207-211. (PMID: 34645181)
J Infect. 2018 May;76(5):429-437. (PMID: 29406154)
J Antimicrob Chemother. 2021 Apr 13;76(5):1155-1159. (PMID: 33517418)
N Engl J Med. 2001 May 3;344(18):1378-88. (PMID: 11333996)
BMC Genomics. 2014 Dec 18;15:1138. (PMID: 25523208)
Mol Biol Evol. 2015 Jan;32(1):268-74. (PMID: 25371430)
Vaccine. 2021 May 6;39(19):2719-2729. (PMID: 33858720)
Pediatr Infect Dis J. 1987 May;6(5):438-9. (PMID: 3110727)
J Antimicrob Chemother. 2017 Jan;72(1):95-98. (PMID: 27733517)
Biochemistry. 2010 Sep 21;49(37):8062-70. (PMID: 20704258)
Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Feb 10;40(2):123-128. (PMID: 30744259)
Sex Transm Infect. 2017 Sep;93(6):445-451. (PMID: 28137933)
Hum Vaccin Immunother. 2022 Nov 30;18(5):2071077. (PMID: 35687866)
J Infect. 2015 Jan;70(1):37-43. (PMID: 25107632)
Emerg Infect Dis. 2021 Apr;27(4):1110-1122. (PMID: 33754991)
Wellcome Open Res. 2018 Sep 24;3:124. (PMID: 30345391)
- Grant Information:
United Kingdom WT_ Wellcome Trust
- Contributed Indexing:
Keywords: CC4821; China; Neisseria meningitidis; Shanghai; antimicrobial resistance; bacteria; clonal complex 4821; horizontal gene transfer; multidrug resistance; penicillin; third-generation cephalosporins
- الرقم المعرف:
0 (Penicillins)
0 (Quinolones)
N2GI8B1GK7 (Cefotaxime)
0 (Anti-Bacterial Agents)
- الموضوع:
Date Created: 20230124 Date Completed: 20230126 Latest Revision: 20240415
- الموضوع:
20240415
- الرقم المعرف:
PMC9881793
- الرقم المعرف:
10.3201/eid2902.221066
- الرقم المعرف:
36692352
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