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LINC02870 facilitates SNAIL translation to promote hepatocellular carcinoma progression.
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- المؤلفون: Guo M;Guo M; Zhuang H; Zhuang H; Huang J; Huang J; Shao X; Shao X; Bai N; Bai N; Li M; Li M; Niu M; Niu M; Wei W; Wei W; Sun L; Sun L; Li Y; Li Y; Qiang Z; Qiang Z
- المصدر:
Molecular and cellular biochemistry [Mol Cell Biochem] 2023 Sep; Vol. 478 (9), pp. 1899-1914. Date of Electronic Publication: 2022 Dec 30.- نوع النشر :
Journal Article- اللغة:
English - المصدر:
- معلومة اضافية
- المصدر: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
- بيانات النشر: Publication: New York : Springer
Original Publication: The Hague, Dr. W. Junk B. V. Publishers. - الموضوع: Carcinoma, Hepatocellular*/pathology ; Liver Neoplasms*/pathology ; RNA, Long Noncoding*/genetics ; RNA, Long Noncoding*/metabolism ; MicroRNAs*/genetics; Humans ; Signal Transduction ; Cell Transformation, Neoplastic/genetics ; Carcinogenesis/genetics ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Cell Line, Tumor ; Cell Movement
- نبذة مختصرة : Exploring the roles of long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis could contribute to the recognition of novel diagnostic and therapeutic targets. LINC02870 is a novel lncRNA, whose role in tumors has not been reported. Herein, we focused on the function and mechanism of LINC02870 in human hepatocellular carcinoma (HCC). We first carried out a pan-cancer study of LINC02870 expression and its relationship to prognosis, and LINC02870 was determined to be a possible oncogene in HCC. Upregulated expressions of LINC02870 were also found in our HCC samples compared to the para-tumor samples. Moreover, overexpression of LINC02870 promoted the growth, migration, and invasion of HCC cells. Subsequently, binding proteins of LINC02870 were identified by a number of in silico analyses, including correlation analysis, signaling network analysis, and survival analysis. Intriguingly, the most promising binding protein of LINC02870 was predicted and confirmed to be eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), an important component of the eukaryotic translation initiation factor 4F complex that initiates cap-dependent translation. Further investigation showed that LINC02870 increased the translation of SNAIL to induce malignant phenotypes in HCC cells. Additionally, HCC patients with higher expression levels of LINC02870 and EIF4G1 had shorter survival times than those with lower expression levels. Thus, our findings suggested that LINC02870 induced SNAIL translation and correlated with poor prognosis and tumor progression in HCC.
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- الرقم المعرف: 0 (RNA, Long Noncoding)
0 (MicroRNAs) - الموضوع: Date Created: 20221230 Date Completed: 20230721 Latest Revision: 20230721
- الموضوع: 20231215
- الرقم المعرف: 10.1007/s11010-022-04575-1
- الرقم المعرف: 36583796
- المصدر:
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