Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.

Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9105195 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2184 (Electronic) Linking ISSN: 09607722 NLM ISO Abbreviation: Cell Prolif Subsets: MEDLINE

Original Publication: [Oxford, England] : Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications, 1991-

Eukaryotic Initiation Factor-4G*/genetics ; Eukaryotic Initiation Factor-4G*/metabolism ; Protein Biosynthesis*; Apoptosis ; Cell Differentiation ; Eukaryotic Initiation Factor-4E/genetics ; Eukaryotic Initiation Factor-4E/metabolism ; Protein Processing, Post-Translational ; Humans

Protein translation is a critical regulatory event involved in nearly all physiological and pathological processes. Eukaryotic translation initiation factors are dedicated to translation initiation, the most highly regulated stage of protein synthesis. Eukaryotic translation initiation factor 4G2 (eIF4G2, also called p97, NAT1 and DAP5), an eIF4G family member that lacks the binding sites for 5' cap binding protein eIF4E, is widely considered to be a key factor for internal ribosome entry sites (IRESs)-mediated cap-independent translation. However, recent findings demonstrate that eIF4G2 also supports many other translation initiation pathways. In this review, we summarize the role of eIF4G2 in a variety of cap-independent and -dependent translation initiation events. Additionally, we also update recent findings regarding the role of eIF4G2 in apoptosis, cell survival, cell differentiation and embryonic development. These studies reveal an emerging new picture of how eIF4G2 utilizes diverse translational mechanisms to regulate gene expression.
(© 2022 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.)

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2020YFA0707704 National Science and Technology Major Project; 2018YFA0106902 National Science and Technology Major Project; 2021C10 Jilin Provincial Development and Reform Commission; 2016Q035 Health Commission of Jilin Province; JLSWSRCZX2020-023 Department of Finance of Jilin Province; 31871297 National Natural Science Foundation of China; I01 BX002905 United States BX BLRD VA; 82050003 National Natural Science Foundation of China; JLSWSRCZX2020-100 Department of Finance of Jilin Province; RT2-01942 California Institute of Regenerative Medicine; 32000431 National Natural Science Foundation of China; BX002905 US Department of Veterans Affairs

0 (Eukaryotic Initiation Factor-4E)
0 (Eukaryotic Initiation Factor-4G)

Date Created: 20221222 Date Completed: 20230309 Latest Revision: 20230331

20240829

PMC9977666

10.1111/cpr.13367

36547008