Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Prolonging the time of progesterone supplementation to improve the pregnancy outcomes of single day 6 blastocyst transfer in frozen-thawed cycles: study protocol for a randomized controlled trial.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, 2006-
    • الموضوع:
      Pregnancy Outcome* ; Infertility*/therapy; Pregnancy ; Female ; Infant, Newborn ; Humans ; Progesterone ; Live Birth ; Cryopreservation/methods ; Embryo Transfer/methods ; Pregnancy Rate ; Fertilization in Vitro/methods ; Dietary Supplements ; Retrospective Studies ; Randomized Controlled Trials as Topic
    • نبذة مختصرة :
      Background: Infertility is one of the most important and underappreciated reproductive health problems in developing countries. Currently, in vitro fertilization and embryo transfer is the most effective treatment strategy for infertility. In a frozen-thawed cycle, single-blastocyst transfer can not only ensure relatively higher pregnancy and live birth rates but also effectively reduce the risk of maternal and neonatal complications. In frozen-thawed cycles, progesterone is initiated to promote the final phase of endometrial preparation prior to embryo transfer. However, the optimal duration of exposure to progesterone has remained inconclusive. Therefore, we designed a randomized controlled trial (RCT) to compare the effects of different prolonged progesterone transformation times (P+6 and P+7) on the pregnancy outcomes of D6 single blastocyst transfer in a frozen-thawed cycle.
      Methods: This is a single-center, prospective, randomized controlled clinical trial involving 900 patients with single blastocyst transfer in the frozen-thawed cycle, aged from 20 to 38 years, with less than three transfers, and with HRT-cycle single D6 blastocyst transfer in the current cycle. Participants will be randomly assigned (1:1) into two parallel groups: the transfer of day 6 blastocysts on the 7th day of progesterone supplementation and the transfer of day 6 blastocysts on the 6th day of progesterone supplementation. The primary outcome measure is the clinical pregnancy rate. Secondary outcome measures include the miscarriage rate and live birth rate.
      Discussion: This is the first randomized controlled trial to compare the transfer of day 6 blastocysts on the 6th and 7th day of progesterone supplementation. The results of this study will provide evidence for whether to prolong the duration of exposure to progesterone prior to embryo transfer.
      Trial Registration: ClinicalTrials.gov, ID: NCT04938011. Registered on 19 June 2021.
      (© 2022. The Author(s).)
    • References:
      N Engl J Med. 2006 Mar 16;354(11):1139-46. (PMID: 16540614)
      Hum Reprod. 2017 Nov 1;32(11):2234-2242. (PMID: 29025055)
      Hum Reprod. 2005 Nov;20(11):3198-203. (PMID: 16055454)
      Fertil Steril. 2008 Jan;89(1):31-2. (PMID: 17511991)
      Fertil Steril. 2014 May;101(5):1294-301. (PMID: 24582521)
      Exp Ther Med. 2022 May;23(5):333. (PMID: 35401807)
      J Assist Reprod Genet. 2022 Feb;39(2):379-388. (PMID: 35064434)
      J Assist Reprod Genet. 2015 Oct;32(10):1483-90. (PMID: 26400506)
      Gynecol Endocrinol. 2017 Oct;33(10):783-786. (PMID: 28443690)
      Fertil Steril. 2008 Jan;89(1):20-6. (PMID: 17224151)
      Hum Reprod. 2018 Mar 1;33(3):390-398. (PMID: 29394365)
      J Assist Reprod Genet. 2017 Jul;34(7):913-919. (PMID: 28500451)
      JAMA Netw Open. 2021 Sep 1;4(9):e2123634. (PMID: 34505887)
      Fertil Steril. 2004 May;81(5):1333-43. (PMID: 15136099)
      Fertil Steril. 2013 Feb;99(2):508-17. (PMID: 23102856)
      Fertil Steril. 2020 Jul;114(1):125-132. (PMID: 32553469)
      Hum Reprod. 2017 Jun 1;32(6):1238-1243. (PMID: 28398477)
      Reprod Biomed Online. 2009 Jan;18(1):85-94. (PMID: 19146774)
      Hum Reprod. 2018 Jun 1;33(6):991-997. (PMID: 29648640)
      Fertil Steril. 1992 Sep;58(3):537-42. (PMID: 1521649)
    • Contributed Indexing:
      Keywords: Blastocyst; Endometrial preparation; Frozen-thawed embryo transfer; Randomized controlled trial
    • Molecular Sequence:
      ClinicalTrials.gov NCT04938011
    • الرقم المعرف:
      4G7DS2Q64Y (Progesterone)
    • الموضوع:
      Date Created: 20221219 Date Completed: 20221221 Latest Revision: 20221222
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC9764536
    • الرقم المعرف:
      10.1186/s13063-022-07013-1
    • الرقم المعرف:
      36536470