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Placental extracellular vesicles in maternal-fetal communication during pregnancy.

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  • معلومة اضافية
    • المصدر:
      Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Portland Press On The Behalf Of The Biochemical Society
    • الموضوع:
      Extracellular Vesicles*/metabolism ; Pre-Eclampsia*/metabolism ; Pre-Eclampsia*/pathology; Pregnancy ; Female ; Humans ; Placenta/metabolism ; Trophoblasts/metabolism ; Communication
    • نبذة مختصرة :
      For several years, a growing number of studies have highlighted the pivotal role of placental extracellular vesicles (EVs) throughout pregnancy. These membrane nanovesicles, heterogeneous in nature, composition and origin, are secreted by several trophoblastic cell types and are found in both the maternal and fetal compartments. They can be uptaken by recipient cells and drive a wide variety of physiological and pathological processes. In this review, we provide an overview of the different described roles of placental EVs in various aspects of normal pregnancy, from placenta establishment to maternal immune tolerance towards the fetus and protection against viral infections. In the second part, we present selected examples of pathological pregnancies in which placental EVs are involved, such as gestational diabetes mellitus, pre-eclampsia, and congenital infections. Since the abundance and/or composition of placental EVs is deregulated in maternal serum during pathological pregnancies, this makes them interesting candidates as non-invasive biomarkers for gestational diseases and opens a wide field of translational perspectives.
      (© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
    • Contributed Indexing:
      Keywords: cell-cell communication; extracellular vesicles; placenta; pregnancy
    • الموضوع:
      Date Created: 20221209 Date Completed: 20221220 Latest Revision: 20221222
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1042/BST20220734
    • الرقم المعرف:
      36484632