Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Multiple levels of stochasticity accounted for in different radiation biophysical models: from physics to biology.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 8809243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-3095 (Electronic) Linking ISSN: 09553002 NLM ISO Abbreviation: Int J Radiat Biol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London ; New York : Taylor & Francis, [c1988-
    • الموضوع:
      Radiobiology* ; Physics*; Computer Simulation ; Cell Survival ; Monte Carlo Method
    • نبذة مختصرة :
      Purpose: In the present paper we investigate how some stochastic effects are included in a class of radiobiological models with particular emphasis on how such randomnesses reflect into the predicted cell survival curve.
      Materials and Methods: We consider four different models, namely the Generalized Stochastic Microdosimetric Model GSM 2 , in its original full form, the Dirac GSM 2 the Poisson GSM 2 and the Repair-Misrepair Model (RMR). While GSM 2 and the RMR models are known in literature, the Dirac and the Poisson GSM 2   have been newly introduced in this work. We further numerically investigate via Monte Carlo simulation of four different particle beams, how the proposed stochastic approximations reflect into the predicted survival curves. To achieve these results, we consider different ion species at energies of interest for therapeutic applications, also including a mixed field scenario.
      Results: We show how the Dirac GSM 2 , the Poisson GSM 2 and the RMR can be obtained from the GSM 2 under suitable approximations on the stochasticity considered. We analytically derive the cell survival curve predicted by the four models, characterizing rigorously the high and low dose limits. We further study how the theoretical findings emerge also using Monte Carlo numerical simulations.
      Conclusions: We show how different models include different levels of stochasticity in the description of cellular response to radiation. This translates into different cell survival predictions depending on the radiation quality.
    • Contributed Indexing:
      Keywords: Stochastic radiobiological models; cell survival assessment; microdosimetry; radiation biophysical modeling
    • الموضوع:
      Date Created: 20221130 Date Completed: 20230427 Latest Revision: 20230511
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1080/09553002.2023.2146230
    • الرقم المعرف:
      36448923