Ent -Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Euphorbia*/chemistry ; Diterpenes*/chemistry ; Antineoplastic Agents*/analysis ; Neoplasms* ; Antineoplastic Agents, Phytogenic*/chemistry; Humans ; Abietanes/pharmacology ; Abietanes/analysis ; Plant Roots/chemistry ; Molecular Structure

The roots of Euphorbia fischeriana have been used as a traditional Chinese medicine for the treatment of tuberculosis and ringworm. In the current study, diterpenoids from the ethyl acetate extract of the roots E. fischeriana and their cytotoxic effects against five cancer lines were investigated. Two new ent -abietane diterpenoids, euphonoids H and I ( 1 - 2 ), as well as their two analogues ( 3 - 4 ) were first isolated from this source. The structures of the two new compounds were elucidated on the basis of spectroscopic data and quantum chemical calculation. Their absolute configurations were assigned via ECD spectrum calculation. The isolated compounds were evaluated for their antiproliferative activities against five cancer cell lines. Compounds 1 and 2 exhibited significant inhibitory effects against human prostate cancers C4-2B and C4-2B/ENZR cell lines with IC 50 values ranging from 4.16 ± 0.42 to 5.74 ± 0.45 μM.

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19NSP077 the New-shoot Talents Project of Guizhou Medical University; [2020]6011 the Scientific Research Foundation for Innovative Talent of Guizhou Province; 22167009 National Natural Science Foundation of China; [2020]5006 the Project of Science and Technology Department of Guizhou Province; ZK[2021]554 the Project of Science and Technology Department of Guizhou Province

Keywords: Euphorbia fischeriana; abietane-type; antiproliferative activities; diterpenoid

0 (Abietanes)
0 (Diterpenes)
0 (Antineoplastic Agents)
0 (Antineoplastic Agents, Phytogenic)

Date Created: 20221111 Date Completed: 20221114 Latest Revision: 20221117

20231215

PMC9653608

10.3390/molecules27217258

36364087