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Toxic Encephalopathy and Methemoglobinemia after 5-Amino-2-(trifluoromethyl)pyridine Poisoning.

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  • المؤلفون: Tao Y;Tao Y;Tao Y; Shi L; Shi L; Han J; Han J; Jian X; Jian X; Li Y; Li Y; Li Y
  • المصدر:
    International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Oct 28; Vol. 19 (21). Date of Electronic Publication: 2022 Oct 28.
  • نوع النشر :
    Case Reports; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel : MDPI, c2004-
    • الموضوع:
      Methemoglobinemia*/chemically induced ; Methemoglobinemia*/drug therapy ; Anemia, Hemolytic*/drug therapy ; Neurotoxicity Syndromes* ; Poisoning*; Male ; Humans ; Adult ; Methylene Blue ; Pyridines/toxicity ; Pyridines/therapeutic use
    • نبذة مختصرة :
      The aromatic amino compound 5-amino-2-(trifluoromethyl)pyridine acts as an intermediate in the synthesis of pharmaceutical products. However, the toxicity profile of this compound is sparse and no related poisoning events have been reported. Here, we report the case of a 35-year-old man who inhaled 5-amino-2-(trifluoromethyl)pyridine at work. After inhalation, the patient rapidly developed symptoms such as dizziness, fatigue, nausea, vomiting, chest tightness, and loss of consciousness. After admission, methemoglobinemia, hemolytic anemia, acute renal failure, and toxic encephalopathy occurred. Symptoms improved significantly after intravenous treatment with a low dose of methylene blue. This revealed that 5-amino-2-(trifluoromethyl)pyridine is toxic to the human body and can be absorbed through the respiratory tract, resulting in methemoglobinemia and toxic encephalopathy; thus, caution should be taken in industrial production.
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    • Contributed Indexing:
      Keywords: 5-amino-2-(trifluoromethyl)pyridine; acute renal failure; magnetic resonance imaging; methemoglobinemia; toxic encephalopathy
    • الرقم المعرف:
      T42P99266K (Methylene Blue)
      0 (Pyridines)
    • الموضوع:
      Date Created: 20221111 Date Completed: 20221114 Latest Revision: 20230119
    • الموضوع:
      20230120
    • الرقم المعرف:
      PMC9656071
    • الرقم المعرف:
      10.3390/ijerph192114031
    • الرقم المعرف:
      36360910