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Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science, [2003]-
    • الموضوع:
      Zika Virus*/physiology ; Zika Virus Infection* ; Aedes* ; Epidemics*; Animals ; Humans ; Cabo Verde ; Saliva ; Mosquito Vectors
    • نبذة مختصرة :
      The explosive emergence of Zika virus (ZIKV) across the Pacific and Americas since 2007 was associated with hundreds of thousands of human cases and severe outcomes, including congenital microcephaly caused by ZIKV infection during pregnancy. Although ZIKV was first isolated in Uganda, Africa has so far been exempt from large-scale ZIKV epidemics, despite widespread susceptibility among African human populations. A possible explanation for this pattern is natural variation among populations of the primary vector of ZIKV, the mosquito Aedes aegypti. Globally invasive populations of Ae. aegypti outside of Africa are considered effective ZIKV vectors because they are human specialists with high intrinsic ZIKV susceptibility, whereas African populations of Ae. aegypti across the species' native range are predominantly generalists with low intrinsic ZIKV susceptibility, making them less likely to spread viruses in the human population. We test this idea by studying a notable exception to the patterns observed across most of Africa: Cape Verde experienced a large ZIKV outbreak in 2015 to 2016. We find that local Ae. aegypti in Cape Verde have substantial human-specialist ancestry, show a robust behavioral preference for human hosts, and exhibit increased susceptibility to ZIKV infection, consistent with a key role for variation among mosquito populations in ZIKV epidemiology. These findings suggest that similar human-specialist populations of Ae. aegypti in the nearby Sahel region of West Africa, which may be expanding in response to rapid urbanization, could serve as effective vectors for ZIKV in the future.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      J Gen Virol. 2018 Sep;99(9):1248-1252. (PMID: 29975185)
      Lancet Infect Dis. 2019 Oct;19(10):1138-1147. (PMID: 31559967)
      Parasit Vectors. 2020 Sep 21;13(1):481. (PMID: 32958043)
      Emerg Infect Dis. 2020 Jun;26(6):1084-1090. (PMID: 32441631)
      Curr Biol. 2016 Jan 11;26(1):R41-6. (PMID: 26766234)
      Nature. 2014 Nov 13;515(7526):222-7. (PMID: 25391959)
      Arch Med Res. 2002 Jul-Aug;33(4):379-88. (PMID: 12234528)
      J Vector Ecol. 2010 Dec;35(2):307-12. (PMID: 21175936)
      Nat Commun. 2021 Feb 10;12(1):916. (PMID: 33568638)
      BMC Biol. 2017 Feb 28;15(1):16. (PMID: 28241828)
      PLoS Negl Trop Dis. 2014 Feb 06;8(2):e2681. (PMID: 24516683)
      Curr Biol. 2020 Sep 21;30(18):3570-3579.e6. (PMID: 32707056)
      Science. 2014 Oct 10;346(6206):234-7. (PMID: 25301627)
      Ecol Evol. 2018 Jul 13;8(16):7835-7848. (PMID: 30250667)
      Trans R Soc Trop Med Hyg. 1952 Sep;46(5):509-20. (PMID: 12995440)
      Emerg Infect Dis. 2020 May;26(5):945-952. (PMID: 32310065)
      Annu Rev Med. 2018 Jan 29;69:395-408. (PMID: 28846489)
      N Engl J Med. 2009 Jun 11;360(24):2536-43. (PMID: 19516034)
      Cell Host Microbe. 2019 Sep 11;26(3):309-313. (PMID: 31513769)
      Bull World Health Organ. 1972;47(5):680-3. (PMID: 4540689)
      PLoS Med. 2017 Jan 3;14(1):e1002203. (PMID: 28045901)
      Lancet Planet Health. 2020 Sep;4(9):e416-e423. (PMID: 32918887)
      Int J Environ Res Public Health. 2018 Jan 28;15(2):. (PMID: 29382107)
      N Engl J Med. 2019 Oct 10;381(15):1444-1457. (PMID: 31597021)
      Science. 2020 Nov 20;370(6519):991-996. (PMID: 33214283)
      Mol Ecol. 2016 Nov;25(21):5377-5395. (PMID: 27671732)
      Bioscience. 2018 Nov 1;68(11):854-860. (PMID: 30464351)
      Ecol Evol. 2021 Nov 09;11(22):16327-16343. (PMID: 34824830)
      Am J Trop Med Hyg. 2018 Sep;99(3):756-763. (PMID: 29988000)
      Evol Appl. 2019 Aug 03;12(9):1797-1811. (PMID: 31548858)
      Trans R Soc Trop Med Hyg. 2017 Nov 1;111(11):527-529. (PMID: 29394415)
      Annu Rev Entomol. 2020 Jan 7;65:191-208. (PMID: 31594415)
      PLoS Pathog. 2012;8(4):e1002588. (PMID: 22496640)
    • Grant Information:
      R00 DC012069 United States DC NIDCD NIH HHS
    • الموضوع:
      Date Created: 20221026 Date Completed: 20221028 Latest Revision: 20240524
    • الموضوع:
      20240524
    • الرقم المعرف:
      PMC9604947
    • الرقم المعرف:
      10.1371/journal.pbio.3001864
    • الرقم المعرف:
      36288328