25-Hydroxyvitamin D Serum Levels Linked to Single Nucleotide Polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in Skeletal Muscle Aging in Institutionalized Elderly Men Not Supplemented with Vitamin D.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Cholestanetriol 26-Monooxygenase*/genetics ; Cytochrome P450 Family 2*/genetics ; Receptors, Calcitriol*/genetics ; Sarcopenia*/genetics ; Vitamin D Deficiency*/genetics ; Vitamin D-Binding Protein*/genetics; Aged ; Aging/genetics ; Calcifediol ; Genotype ; Humans ; Male ; Muscle, Skeletal ; Polymorphism, Single Nucleotide ; Vitamin D/analogs & derivatives ; Vitamins

Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in an involution of muscle function and strength. Vitamin D deficiency is a common health problem worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders. The aim of this study was to evaluate the impact and presence of a possible linkage between Single Nucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570), serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalized elderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified with a commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASPar assays. Significant differences in 25-OH/D concentration were determined between the bi-allelic combinations of rs228679 and rs228570. We detected statistically significant weak positive correlations between the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and the probability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GG alleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreases by 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlation between the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree of sarcopenia in institutionalized elderly people.

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SO-1-2020 Chair of Knowledge and Innovation "Caja Rural de Soria" University of Valladolid Campus de Soria (Spain)

Keywords: 25-OH vitamin D; CYP2R1; GC; VDR; aging; deficiency; elderly; genetics; sarcopenia

0 (GC protein, human)
0 (Receptors, Calcitriol)
0 (VDR protein, human)
0 (Vitamin D-Binding Protein)
0 (Vitamins)
1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)
EC 1.14.14.1 (Cytochrome P450 Family 2)
EC 1.14.14.24 (CYP2R1 protein, human)
EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase)
P6YZ13C99Q (Calcifediol)

Date Created: 20221014 Date Completed: 20221017 Latest Revision: 20221019

20221213

PMC9569711

10.3390/ijms231911846

36233147