Deciphering the Basis of Molecular Biology of Selected Cardiovascular Diseases: A View on Network Medicine.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Cardiovascular Diseases*/drug therapy ; Cardiovascular Diseases*/genetics ; Heart Diseases* ; Medicine*; Forecasting ; Humans ; Molecular Biology

Cardiovascular diseases are the leading cause of death across the world. For decades, researchers have been studying the causes of cardiovascular disease, yet many of them remain undiscovered or poorly understood. Network medicine is a recently expanding, integrative field that attempts to elucidate this issue by conceiving of disease as the result of disruptive links between multiple interconnected biological components. Still in its nascent stages, this revolutionary application of network science facilitated a number of important discoveries in complex disease mechanisms. As methodologies become more advanced, network medicine harbors the potential to expound on the molecular and genetic complexities of disease to differentiate how these intricacies govern disease manifestations, prognosis, and therapy. This is of paramount importance for confronting the incredible challenges of current and future cardiovascular disease research. In this review, we summarize the principal molecular and genetic mechanisms of common cardiac pathophysiologies as well as discuss the existing knowledge on therapeutic strategies to prevent, halt, or reverse these pathologies.

N Engl J Med. 2009 Apr 9;360(15):1526-38. (PMID: 19357408)
Curr Cardiol Rep. 2021 May 7;23(6):58. (PMID: 33961130)
Circ Cardiovasc Imaging. 2014 Jul;7(4):619-28. (PMID: 24782115)
Curr Top Dev Biol. 2017;122:195-221. (PMID: 28057264)
J Korean Med Sci. 1999 Apr;14(2):138-46. (PMID: 10331558)
J Cardiothorac Vasc Anesth. 2019 Jan;33(1):209-222. (PMID: 30029992)
Int J Biochem Cell Biol. 2005 Sep;37(9):1746-51. (PMID: 15950518)
Mol Ther. 2009 Jun;17(6):1109-15. (PMID: 19352324)
Annu Rev Med. 2002;53:319-36. (PMID: 11818477)
Cell Metab. 2015 Feb 3;21(2):174-182. (PMID: 25651172)
Circ Res. 2021 May 14;128(10):1487-1513. (PMID: 33983836)
Lancet. 2015 Aug 22;386(9995):743-800. (PMID: 26063472)
Pharmacoeconomics. 2020 Nov;38(11):1219-1236. (PMID: 32812149)
Nature. 1998 Mar 19;392(6673):293-6. (PMID: 9521325)
Tissue Cell. 2022 Aug;77:101850. (PMID: 35679684)
Circulation. 1999 Jun 22;99(24):3099-102. (PMID: 10377071)
J Biol Chem. 2010 Aug 6;285(32):24447-56. (PMID: 20529848)
Mol Biol Rep. 2010 Apr;37(4):2075-81. (PMID: 19680789)
Biochim Biophys Acta. 2016 Oct;1861(10):1525-34. (PMID: 26996746)
J Clin Invest. 1988 Dec;82(6):2017-25. (PMID: 3198763)
Curr Opin Cardiol. 2005 May;20(3):182-8. (PMID: 15861005)
Nat Rev Genet. 2011 May;12(5):357-62. (PMID: 21423240)
Bioconjug Chem. 2011 Aug 17;22(8):1706-14. (PMID: 21749133)
Gene Ther. 2012 Aug;19(8):836-43. (PMID: 21918549)
Nat Cell Biol. 2011 Apr;13(4):434-46. (PMID: 21441927)
Circulation. 2004 Apr 6;109(13):1590-3. (PMID: 15051637)
Nat Rev Genet. 2011 Jan;12(1):56-68. (PMID: 21164525)
J Am Coll Cardiol. 2012 Aug 21;60(8):705-15. (PMID: 22796258)
Curr Opin Cardiol. 2021 May 1;36(3):288-294. (PMID: 33769382)
Curr Opin Cardiol. 2012 May;27(3):202-9. (PMID: 22382498)
Nature. 2011 Jun 08;474(7353):649-53. (PMID: 21654750)
Heart. 2015 Jul;101(14):1159-68. (PMID: 25855795)
Heart Fail Rev. 2017 Jan;22(1):91-98. (PMID: 27904993)
J Intern Med. 2021 Sep;290(3):567-582. (PMID: 34033164)
Int J Mol Sci. 2021 Jan 08;22(2):. (PMID: 33429969)
Cell. 1995 Mar 10;80(5):805-11. (PMID: 7889574)
Catheter Cardiovasc Interv. 2013 Nov 15;82(6):899-906. (PMID: 22777825)
Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):1051-8. (PMID: 20074469)
Clin Sci (Lond). 2004 Dec;107(6):539-57. (PMID: 15341511)
Diabetologia. 2012 Jul;55(7):2032-43. (PMID: 22476949)
Lancet. 2013 Jan 19;381(9862):242-55. (PMID: 22874472)
Heart. 2003 Aug;89(8):848-53. (PMID: 12860855)
Am Heart J. 2011 Mar;161(3):581-9. (PMID: 21392615)
J Card Fail. 2018 May;24(5):281-302. (PMID: 29567486)
Prog Cardiovasc Dis. 1985 Jan-Feb;27(4):255-70. (PMID: 3880919)
Eur Heart J. 2015 Nov 7;36(42):2921-2964. (PMID: 26320112)
Nat Rev Cardiol. 2021 Jan;18(1):22-36. (PMID: 32895535)
Acta Biomed. 2019 Sep 30;90(10-S):32-43. (PMID: 31577251)
Lancet. 2020 Sep 12;396(10253):736-737. (PMID: 32871101)
Circulation. 2002 Apr 23;105(16):1989-94. (PMID: 11997288)
Lancet. 2016 Mar 19;387(10024):1178-86. (PMID: 26803443)
Nat Rev Genet. 2004 Nov;5(11):811-25. (PMID: 15520791)
Arthritis Rheum. 2002 Aug;46(8):2181-8. (PMID: 12209523)
Stem Cells. 2007 Mar;25(3):712-7. (PMID: 17138964)
J Cardiovasc Pharmacol. 2019 Sep;74(3):175-187. (PMID: 31356555)
Int J Cardiol. 2014 Feb 15;171(3):368-76. (PMID: 24398230)
Biochem Biophys Res Commun. 2001 May 11;283(3):549-53. (PMID: 11341759)
Egypt Heart J. 2022 Jan 21;74(1):5. (PMID: 35061126)
Cardiovasc Res. 2021 Feb 22;117(3):820-835. (PMID: 32259211)
Wiley Interdiscip Rev Dev Biol. 2017 Jan;6(1):. (PMID: 27626243)
J Am Heart Assoc. 2022 Jun 7;11(11):e024931. (PMID: 35658515)
Lancet. 2017 Jul 22;390(10092):400-414. (PMID: 28190577)
Circulation. 1990 Dec;82(6):2217-21. (PMID: 2173647)
J Am Coll Cardiol. 2015 Dec 29;66(25):2913-2914. (PMID: 26718681)
Int J Cardiol. 2022 Jun 15;357:55-71. (PMID: 35364138)
N Engl J Med. 2013 Oct 17;369(16):1522-8. (PMID: 23992557)
PLoS Comput Biol. 2012;8(12):e1002819. (PMID: 23300410)
Circ Res. 2020 Apr 24;126(9):1260-1280. (PMID: 32324502)
Int J Cardiovasc Res. 2016 Jan 3;5(1):. (PMID: 27468412)
Arq Bras Cardiol. 2014 Mar;102(3):295-304. (PMID: 24714796)
Glob Cardiol Sci Pract. 2018 Aug 12;2018(3):36. (PMID: 30393648)
J Intern Med. 2003 Feb;253(2):120-7. (PMID: 12542551)
J Cardiovasc Transl Res. 2010 Feb;3(1):37-48. (PMID: 20560033)
N Engl J Med. 2018 Nov 29;379(22):2097-2107. (PMID: 30403574)
Mol Ther. 2011 Sep;19(9):1582-90. (PMID: 21792180)
J Pineal Res. 2020 Sep;69(2):e12666. (PMID: 32369647)
Microvasc Res. 2010 Jul;80(1):10-7. (PMID: 20045007)
Am J Epidemiol. 1986 Jan;123(1):48-58. (PMID: 3940442)
Cold Spring Harb Perspect Med. 2013 Oct 01;3(10):a013847. (PMID: 24086063)
JACC Heart Fail. 2020 Jul;8(7):523-536. (PMID: 32535126)
Mol Biol Rep. 2009 Jul;36(6):1323-9. (PMID: 18649012)
FEBS J. 2005 Jun;272(11):2684-95. (PMID: 15943803)
Circ Res. 2007 Aug 17;101(4):335-47. (PMID: 17702980)
Arch Biochem Biophys. 2016 Jul 1;601:11-21. (PMID: 26851561)
Circ Res. 2013 Aug 30;113(6):660-75. (PMID: 23989711)
Circulation. 2006 Aug 1;114(5):388-96. (PMID: 16864723)
J Am Coll Cardiol. 2015 Mar 31;65(12):1249-1254. (PMID: 25814232)
Front Cardiovasc Med. 2017 Sep 01;4:54. (PMID: 28920058)
Kardiologiia. 1987 Dec;27(12):45-8. (PMID: 3444212)
J Intern Med. 2019 Oct;286(4):362-372. (PMID: 31132311)
Int J Rheum Dis. 2018 Jan;21(1):45-49. (PMID: 29105303)
Eur Heart J Cardiovasc Pharmacother. 2018 Jan 1;4(1):46-53. (PMID: 28633474)
J Mol Cell Cardiol. 2001 Apr;33(4):655-70. (PMID: 11273720)
Circ Res. 2013 Mar 1;112(5):816-25. (PMID: 23429605)
J Biol Chem. 2000 May 12;275(19):14501-8. (PMID: 10799533)
Hum Gene Ther. 2006 Oct;17(10):1043-8. (PMID: 17007567)
Circulation. 2010 Feb 23;121(7):916-28. (PMID: 20177006)
BMC Public Health. 2018 Aug 6;18(1):975. (PMID: 30081871)
Biochim Biophys Acta. 2016 Oct;1861(10):1513-24. (PMID: 26924249)
Circulation. 2007 May 15;115(19):2506-15. (PMID: 17470693)
J Clin Invest. 2001 Jan;107(2):191-8. (PMID: 11160135)
Am J Pathol. 2009 Aug;175(2):473-8. (PMID: 19590040)
JAMA Cardiol. 2016 May 1;1(2):163-71. (PMID: 27437887)
Circulation. 2011 Jul 19;124(3):304-13. (PMID: 21709064)
Front Pharmacol. 2021 Apr 16;12:623674. (PMID: 33935716)
Gene Ther. 2009 May;16(5):629-34. (PMID: 19212427)
Cureus. 2020 Jul 23;12(7):e9349. (PMID: 32742886)
Diabet Med. 2001 Dec;18(12):945-59. (PMID: 11903393)
Can J Cardiol. 2006 Mar 1;22(3):235-40. (PMID: 16520855)
Exerc Sport Sci Rev. 2006 Apr;34(2):50-3. (PMID: 16672800)
Circ Res. 1993 Jan;72(1):176-86. (PMID: 8417840)
Genome Biol. 2011;12(5):222. (PMID: 21639948)
JACC Heart Fail. 2018 May;6(5):364-375. (PMID: 29655825)
Circulation. 2014 Oct 28;130(18):1601-6. (PMID: 25205801)
Blood Cells Mol Dis. 2004 Jan-Feb;32(1):82-7. (PMID: 14757418)
Nature. 1999 Aug 5;400(6744):576-81. (PMID: 10448861)
Diabetes. 2002 Aug;51(8):2587-95. (PMID: 12145175)
Circ Res. 2018 Aug 17;123(5):614-629. (PMID: 30355136)
Nat Rev Dis Primers. 2019 May 9;5(1):32. (PMID: 31073128)
Circ J. 2010 May;74(5):916-24. (PMID: 20215699)
Circulation. 2010 Jan 26;121(3):426-35. (PMID: 20065164)
Panminerva Med. 2021 Sep;63(3):249-260. (PMID: 33337127)
Eur Heart J. 2005 Jul;26(13):1327-32. (PMID: 15821009)
Circ Res. 2004 Feb 20;94(3):284-95. (PMID: 14976139)
Cells. 2020 Jan 18;9(1):. (PMID: 31963679)
Circ Res. 2017 Sep 15;121(7):711-721. (PMID: 28912178)
N Engl J Med. 1994 Apr 14;330(15):1041-6. (PMID: 8127331)
Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R568-77. (PMID: 17459908)
J Med Virol. 2018 Dec;90(12):1814-1821. (PMID: 30011073)
Cell. 1995 Mar 10;80(5):795-803. (PMID: 7889573)
Circulation. 2016 Dec 6;134(23):e579-e646. (PMID: 27832612)
Circulation. 2000 Nov 7;102(19):2396-401. (PMID: 11067795)
Biochim Biophys Acta. 2016 Oct;1861(10):1555-68. (PMID: 26899197)
Nat Rev Genet. 2012 Feb 07;13(3):175-88. (PMID: 22310894)
Nature. 1999 Aug 5;400(6744):581-5. (PMID: 10448862)
J Am Heart Assoc. 2013 Aug 20;2(4):e000119. (PMID: 23963752)
Circulation. 2001 Mar 6;103(9):1311-6. (PMID: 11238278)
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. (PMID: 33309175)
Circ Res. 2013 Aug 30;113(6):792-809. (PMID: 23989720)
ESC Heart Fail. 2018 Jun;5(3):211-217. (PMID: 29457878)
Acta Physiol Scand. 1992 Jan;144(1):39-45. (PMID: 1595352)
Adv Exp Med Biol. 2001;498:213-20. (PMID: 11900371)

Keywords: cardiovascular disease (CVD); gene therapy; molecular biology; network medicine; system biology

Date Created: 20221014 Date Completed: 20221017 Latest Revision: 20221019

20231215

PMC9569471

10.3390/ijms231911421

36232723