Losing a child to adolescent cancer: A register-based cohort study of psychotropic medication use in bereaved parents.

Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-

Bereavement* ; Parents*/psychology ; Psychotropic Drugs*/adverse effects ; Psychotropic Drugs*/therapeutic use ; Death*; Humans ; Male ; Female ; Adolescent ; Middle Aged ; Sweden ; Anti-Anxiety Agents/adverse effects ; Anti-Anxiety Agents/therapeutic use ; Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/therapeutic use ; Adult ; Neoplasms/mortality

Purpose: To investigate the short- and long-term risk of psychotropic medication use in parents who lose a child to cancer diagnosed in adolescence.
Methods: This is a Swedish nationwide register-based study including 184 bereaved mothers and 184 bereaved fathers of 184 children diagnosed with cancer in adolescence. Logistic regression analyses, adjusted for sociodemographic characteristics and history of mental health problems, were performed to estimate risk of a prescription of psychotropic medication (anxiolytics, hypnotics/sedatives, antidepressants) in cancer-bereaved parents from 1 year before to 5 years after the child's death, with a general population sample of non-bereaved parents (n = 3291) as referents.
Results: At the year of the child's death, 28%-36% of mothers and 11%-20% of fathers had a prescription of anxiolytics, hypnotics/sedatives or antidepressants. The corresponding percentages for non-bereaved mothers and fathers were 7%-12% and 4%-7%, respectively. Compared to non-bereaved mothers, bereaved mothers showed higher odds of prescriptions from 1 year before up to four (anxiolytics) and 5 years (hypnotics/sedatives and antidepressants) after the child's death. Bereaved fathers showed higher odds than non-bereaved fathers of prescriptions from 1 year before up to the year of (anxiolytics and hypnotics/sedatives) and 1 year after (antidepressants) the child's death. No differences in odds between bereaved and non-bereaved fathers were found at 2 years after the child's death. Being unmarried, born outside Sweden, and having a history of mental health problems were associated with higher odds of prescribed medications.
Conclusions: Indicative of mental health problems of clinical importance, cancer-bereaved parents had a higher prevalence of use of psychotropic medication. A decrease in medication use was evident with time, but still at 5 years after the child's death mothers displayed a higher use while fathers showed no difference to non-bereaved fathers after 2 years.
(© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)

Internet Interv. 2021 Jun 05;25:100409. (PMID: 34401368)
Pediatr Blood Cancer. 2012 Apr;58(4):503-12. (PMID: 22038675)
J Palliat Med. 2010 Nov;13(11):1321-6. (PMID: 20954828)
Cancer Med. 2023 Mar;12(5):6148-6160. (PMID: 36218005)
Eur J Oncol Nurs. 2018 Aug;35:22-32. (PMID: 30057080)
Cancer Med. 2022 Nov;11(22):4341-4353. (PMID: 35474312)
Psychooncology. 2019 Jul;28(7):1530-1536. (PMID: 31108000)
Arch Psychiatr Nurs. 2005 Dec;19(6):245-55. (PMID: 16308124)
Curr Oncol Rep. 2013 Aug;15(4):325-31. (PMID: 23700032)
Soc Sci Med. 2006 Nov;63(9):2440-51. (PMID: 16875769)
J Clin Oncol. 2020 Jan 10;38(2):137-144. (PMID: 31725342)
BMJ Glob Health. 2020 Sep;5(9):. (PMID: 32972966)
J Adolesc Young Adult Oncol. 2016 Mar;5(1):48-57. (PMID: 26812452)
Acta Oncol. 2009;48(1):27-33. (PMID: 18767000)
Eur J Oncol Nurs. 2021 Apr;51:101929. (PMID: 33713920)
J Pain Symptom Manage. 2019 Oct;58(4):596-604. (PMID: 31276811)
Methods Mol Biol. 2011;675:215-20. (PMID: 20949391)
J Clin Oncol. 2015 Jul 10;33(20):2246-53. (PMID: 26033819)
Psychooncology. 2017 Sep;26(9):1307-1315. (PMID: 27862627)
PLoS One. 2018 Apr 17;13(4):e0195899. (PMID: 29664926)
Cancer. 2006 Oct 1;107(7 Suppl):1663-71. (PMID: 16921479)
Pediatr Blood Cancer. 2006 Nov;47(6):819-24. (PMID: 16615062)
Lancet. 2003 Feb 1;361(9355):363-7. (PMID: 12573371)
Pediatr Blood Cancer. 2011 Apr;56(4):532-43. (PMID: 21298737)
BMJ Open. 2020 Jun 28;10(6):e038826. (PMID: 32595167)
J Pediatr Psychol. 2015 Sep;40(8):733-43. (PMID: 25840446)
Eur J Epidemiol. 2017 Sep;32(9):765-773. (PMID: 28983736)
N Engl J Med. 2005 Mar 24;352(12):1190-6. (PMID: 15788495)
Psychol Med. 2004 Nov;34(8):1431-41. (PMID: 15724874)
Eur J Epidemiol. 2019 Apr;34(4):423-437. (PMID: 30929112)
J Adv Nurs. 2010 Sep;66(9):1980-90. (PMID: 20626475)
Children (Basel). 2017 Nov 09;4(11):. (PMID: 29120367)
Pediatr Blood Cancer. 2015 Dec;62 Suppl 5:S632-83. (PMID: 26700921)
Acta Oncol. 2019 Jul;58(7):1015-1020. (PMID: 30958083)
PLoS One. 2018 May 2;13(5):e0195500. (PMID: 29718925)
J Consult Clin Psychol. 2005 Aug;73(4):617-23. (PMID: 16173849)
Eur J Epidemiol. 2016 Feb;31(2):125-36. (PMID: 26769609)
Lancet Oncol. 2014 Jan;15(1):35-47. (PMID: 24314616)
Palliat Support Care. 2009 Mar;7(1):109-19. (PMID: 19619380)
Pediatr Blood Cancer. 2015 Dec;62 Suppl 5:S834-69. (PMID: 26700929)
Soc Sci Med. 2019 Oct;239:112522. (PMID: 31487567)
Psychooncology. 2015 Dec;24(12):1792-8. (PMID: 26042579)
BMC Public Health. 2011 Jun 09;11:450. (PMID: 21658213)
Acta Oncol. 2018 Jul;57(7):950-957. (PMID: 29498559)
Int J Cancer. 2020 Dec 15;147(12):3349-3360. (PMID: 32535927)
Pediatrics. 2019 May;143(5):. (PMID: 30944153)
Pharmacoepidemiol Drug Saf. 2007 Jul;16(7):726-35. (PMID: 16897791)
Lancet. 2007 Dec 8;370(9603):1960-73. (PMID: 18068517)
J Pediatr Psychol. 2008 Aug;33(7):694-706. (PMID: 18287109)

Keywords: adolescence; bereavement; cancer; parents; psychotropic medication

0 (Psychotropic Drugs)
0 (Anti-Anxiety Agents)
0 (Antidepressive Agents)
0 (Hypnotics and Sedatives)

Date Created: 20221011 Date Completed: 20231222 Latest Revision: 20231222

20231223

PMC10028064

10.1002/cam4.5347

36218005