Family history of breast cancer, mammographic breast density and breast cancer risk: Findings from a cohort study of Korean women.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE

Publication: 2002- : Amsterdam : Elsevier
Original Publication: Edinburgh ; New York : Churchill Livingstone, c1992-

Breast Density* ; Breast Neoplasms*/diagnostic imaging ; Breast Neoplasms*/epidemiology ; Breast Neoplasms*/genetics; Adult ; Aged ; Cohort Studies ; Female ; Humans ; Mammography ; Middle Aged ; Republic of Korea/epidemiology ; Risk Factors

Background: This study investigated whether the association between family history of breast cancer in first-degree relatives and breast cancer risk varies by breast density.
Methods: Women aged 40 years and older who underwent screening between 2009 and 2010 were followed up until 2020. Family history was assessed using a self-reported questionnaire. Using Breast Imaging Reporting and Data System (BI-RADS), breast density was categorized into dense breast (heterogeneously or extremely dense) and non-dense breast (almost entirely fatty or scattered areas of fibro-glandular). Cox regression model was used to assess the association between family history and breast cancer risk.
Results: Of the 4,835,507 women, 79,153 (1.6%) reported having a family history of breast cancer and 77,238 women developed breast cancer. Family history led to an increase in the 5-year cumulative incidence in women with dense- and non-dense breasts. Results from the regression model with and without adjustment for breast density yielded similar HRs in all age groups, suggesting that breast density did not modify the association between family history and breast cancer. After adjusting for breast density and other factors, family history of breast cancer was associated with an increased risk of breast cancer in all three age groups (age 40-49 years: aHR 1.96, 95% confidence interval [CI] 1.85-2.08; age 50-64 years: aHR 1.70, 95% CI 1.58-1.82, and age ≥65 years: aHR 1.95, 95% CI 1.78-2.14).
Conclusion: Family history of breast cancer and breast density are independently associated with breast cancer. Both factors should be carefully considered in future risk prediction models of breast cancer.
Competing Interests: Declaration of competing interest The authors declare no potential conflicts of interest.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)

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Keywords: Breast cancer risk; Breast density; Family history of breast cancer

Date Created: 20220901 Date Completed: 20220914 Latest Revision: 20240903

20240903

PMC9441334

10.1016/j.breast.2022.08.008

36049384