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Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Carcinoma, Squamous Cell*/pathology ; Head and Neck Neoplasms*/pathology ; Head and Neck Neoplasms*/radiotherapy ; Head and Neck Neoplasms*/surgery; Humans ; Neck Dissection/methods ; Neoplasm Staging ; Prospective Studies ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/radiotherapy ; Squamous Cell Carcinoma of Head and Neck/surgery
    • نبذة مختصرة :
      The significance of postoperative radiotherapy (PORT) to the neck for pN1 status head and neck squamous cell carcinomas (HNSCC) after neck dissection is unclear. A total of 208 patients with pN1 status HNSCC treated from January 1, 2001, to December 31, 2014, were enrolled in the current study. The 5-year regional recurrence-free survival (RRFS), overall survival (OS) and distant metastasis-free survival (DMFS) were compared between patients with or without PORT to the dissected neck. Moreover, the stratified Cox proportional hazards models were used to assess the association between PORT to the neck and survival before and after propensity score matching. Seventy-nine patients received PORT to the neck, while 129 did not. All patients were followed for over 5 years, with a median follow-up duration of 64.6 months. The PORT group did not show better survival results than the group without PORT to the neck in RRFS, OS or DMFS. Moreover, no evidence showed that PORT to the neck was independently associated with 5-year survival. PORT to the neck for pN1 status HNSCC after neck dissection did not lead to better survival. However, it is necessary to conduct prospective randomized clinical trials to confirm these results.
      (© 2022. The Author(s).)
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    • الموضوع:
      Date Created: 20220811 Date Completed: 20220815 Latest Revision: 20221020
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC9372140
    • الرقم المعرف:
      10.1038/s41598-022-17932-3
    • الرقم المعرف:
      35953555