Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis.

Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101658402 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4418 (Print) Linking ISSN: 20754418 NLM ISO Abbreviation: Diagnostics (Basel) Subsets: PubMed not MEDLINE

Original Publication: Basel, Switzerland : MDPI AG, [2011]-

Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the evaluation of the extent of SSc-ILD. Methods: Adult SSc patients underwent pulmonary function tests (PFTs), LUS and CT. The CT images were qualitatively, semi-quantitatively (the Wells score on five levels and the categorical Goh et al. staging) and quantitatively (histogram-based densitometry) analysed for ILD. LUS quantified B-lines in 21 intercostal spaces on both the anterior and posterior chest wall. Results: Out of the 77 SSc patients eligible for the study, 35 presented with ILD on CT (21 limited, 14 extensive). Total B-lines significantly differentiated ILD vs. no ILD (median 24 vs. 8, p < 0.001). Posterior and total B-lines significantly differentiated limited from absent ILD, while anterior B-lines distinguished extensive from limited ILD. Total B-lines correlated with the Wells score (r = 0.446, p < 0.001) and MLA (r = −0.571, p < 0.001); similar results were confirmed when anterior and posterior B-lines were analysed separately. Conclusions: LUS is a useful tool to identify SSc-ILD and to correlate with different evaluations of ILD extent and severity.

Rheumatology (Oxford). 2009 Nov;48(11):1382-7. (PMID: 19717549)
Rheumatology (Oxford). 2017 Jun 1;56(6):922-927. (PMID: 28160007)
Arthritis Care Res (Hoboken). 2021 Sep;73(9):1338-1342. (PMID: 32475026)
Front Med (Lausanne). 2022 Jan 27;8:807982. (PMID: 35155484)
Sci Rep. 2019 Jul 1;9(1):9468. (PMID: 31263199)
Arthritis Rheumatol. 2015 Dec;67(12):3256-61. (PMID: 26316389)
Arthritis Res Ther. 2011 Aug 18;13(4):R134. (PMID: 21851634)
J Scleroderma Relat Disord. 2021 Feb;6(1):11-20. (PMID: 33693057)
Ann Rheum Dis. 2020 Sep;79(9):1210-1217. (PMID: 32606043)
Arthritis Rheum. 1997 Jul;40(7):1229-36. (PMID: 9214422)
Clin Exp Rheumatol. 2022 Oct;40(10):1951-1955. (PMID: 35819810)
J Scleroderma Relat Disord. 2021 Jun;6(2):123-132. (PMID: 35386740)
Diagnostics (Basel). 2021 Dec 07;11(12):. (PMID: 34943531)
Mod Rheumatol. 2015 Sep;25(5):724-30. (PMID: 25736361)
Pharmaceuticals (Basel). 2021 Feb 13;14(2):. (PMID: 33668530)
Ann Rheum Dis. 2013 Mar;72(3):390-5. (PMID: 22589373)
J Scleroderma Relat Disord. 2020 Mar;5(2 Suppl):6-16. (PMID: 35382227)
Rheumatology (Oxford). 2022 Apr 18;61(SI):SI56-SI64. (PMID: 34698807)
J Clin Rheumatol. 2019 Oct;25(7):304-307. (PMID: 30028804)
Am J Respir Crit Care Med. 2008 Jun 1;177(11):1248-54. (PMID: 18369202)
Ann Rheum Dis. 2021 Feb;80(2):219-227. (PMID: 32988845)
Respir Res. 2020 Jul 23;21(1):197. (PMID: 32703199)
Lancet Rheumatol. 2020 Feb;2(2):e71-e83. (PMID: 38263663)
Chest. 2020 Oct;158(4):1515-1525. (PMID: 32360727)
Intern Emerg Med. 2016 Mar;11(2):213-7. (PMID: 26494471)

Keywords: computed tomography; interstitial lung disease; radiomics; systemic sclerosis; ultrasound

Date Created: 20220727 Latest Revision: 20240901

20240901

PMC9316638

10.3390/diagnostics12071696

35885600