Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States.

Publisher: Wiley Country of Publication: United States NLM ID: 8801384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2825 (Electronic) Linking ISSN: 08878013 NLM ISO Abbreviation: J Clin Lab Anal Subsets: MEDLINE

Publication: Hoboken, N.J. : Wiley
Original Publication: New York : Alan R. Liss, Inc., c1987-

Elasticity Imaging Techniques* ; Non-alcoholic Fatty Liver Disease*/diagnostic imaging ; Non-alcoholic Fatty Liver Disease*/epidemiology; Creatinine ; Cross-Sectional Studies ; Female ; Humans ; Male ; Nutrition Surveys ; Prevalence ; Risk Factors ; United States/epidemiology ; Uric Acid

Background: The association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non-alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified. In this study, we investigated the relationship between sUA/Cr and NAFLD among participants in the United States.
Methods: We performed a cross-sectional study based on data from the National Health and Nutrition examination Survey (NHANES) 2017-2018. A measured controlled attenuation parameter (CAP) value of ≥274 dB/m detected by Fibroscan was used to identify hepatic steatosis. SUA/Cr was calculated as sUA divided by serum creatinine. Multivariate logistic regression analysis was used to estimate the association between sUA/Cr and NAFLD. The adjusted odds ratio (OR) of sUA/Cr for NAFLD was estimated, and subgroup analysis stratified by sex was also conducted. The nonlinear relationship between sUA/Cr and NAFLD was further described using smooth curve fittings and threshold-effect analysis.
Results: We found that sUA/Cr was positively correlated with NAFLD status after fully adjustment for confounding factors. In subgroup analysis stratified by sex, the positive interaction between sUA/Cr and NAFLD status only existed in women but not in men. Moreover, the nonlinear association between sUA/Cr and NAFLD status was an inverted U-shaped curve with an inflection point at 9.7 among men.
Conclusions: Our study identified that sUA/Cr was positively associated with the risk of NAFLD among individuals in the United States. Moreover, the correlation between sUA/Cr and NAFLD differed according to sex.
(© 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)

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Keywords: NAFLD; NHANES; inflammation; serum uric acid to creatinine ratio; steatosis

268B43MJ25 (Uric Acid)
AYI8EX34EU (Creatinine)

Date Created: 20220709 Date Completed: 20220824 Latest Revision: 20220826

20221213

PMC9396182

10.1002/jcla.24590

35808891