Association between the Dietary Inflammatory Index and Gastric Disease Risk: Findings from a Korean Population-Based Cohort Study.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Inflammation*/diagnosis ; Inflammation*/epidemiology ; Stomach Diseases*; Cohort Studies ; Cross-Sectional Studies ; Diet/adverse effects ; Humans ; Republic of Korea/epidemiology ; Risk Factors

Evidence suggests that diets with high pro-inflammatory potential may play a substantial role in the origin of gastric inflammation. This study aimed to examine the association between the energy-adjusted dietary inflammatory index (E-DII ^TM ) and gastric diseases at baseline and after a mean follow-up of 7.4 years in a Korean population. A total of 144,196 participants from the Korean Genome and Epidemiology Study_Health Examination (KoGES_HEXA) cohort were included. E-DII scores were computed using a validated semi-quantitative food frequency questionnaire. Multivariate logistic regression and Cox proportional hazards regression were used to assess the association between the E-DII and gastric disease risk. In the prospective analysis, the risk of developing gastric disease was significantly increased among individuals in the highest quartile of E-DII compared to those in the lowest quartile (HR quartile4vs1 = 1.22; 95% CI = 1.08-1.38). Prospective analysis also showed an increased risk in the incidence of gastritis (HR quartile4vs1 = 1.19; 95% CI = 1.04-1.37), gastric ulcers (HR quartile4vs1 = 1.47; 95% CI = 1.16-1.85), and gastric and duodenal ulcers (HR quartile4vs1 = 1.46; 95% CI = 1.17-1.81) in the highest E-DII quartile compared to the lowest quartile. In the cross-sectional analysis, the E-DII score was not associated with the risk of gastric disease. Our results suggest that a pro-inflammatory diet, indicated by high E-DII scores, is prospectively associated with an increased risk of gastric diseases. These results highlight the significance of an anti-inflammatory diet in lowering the risk of gastric disease risk in the general population.

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NCC-2211690 Republic of Korea National Cancer Center

Keywords: anti-inflammatory diet; dietary inflammatory index; gastric diseases; gastritis; pro-inflammatory diet; ulcer

Date Created: 20220709 Date Completed: 20220712 Latest Revision: 20220716

20231215

PMC9268659

10.3390/nu14132662

35807849