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Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
    • الموضوع:
      Heart* ; Ventricular Remodeling*; Transcription Factors/*metabolism; Animals ; Gene Deletion ; Mice
    • نبذة مختصرة :
      Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. We show in exercised mice that the expression of CITED4, a transcriptional co-regulator necessary for cardioprotection, is regionally heterogenous in the heart with preferential significant increases in the lateral wall compared with sedentary mice. Concordantly in this same region, the heart's local microstructural tissue helicity is also selectively increased in exercised mice. Quantification of CITED4 expression and microstructural tissue helicity reveals a significant correlation across both sedentary and exercise mouse cohorts. Furthermore, genetic deletion of CITED4 in the heart prohibits regional exercise-induced microstructural helicity remodeling. Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes.
      (© 2022. The Author(s).)
    • Comments:
      Erratum in: Commun Biol. 2022 Jul 13;5(1):696. doi: 10.1038/s42003-022-03671-8. (PMID: 35831490)
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    • Grant Information:
      R01 NS117694 United States NS NINDS NIH HHS; K99 NS087096 United States NS NINDS NIH HHS; R01 HL151704 United States HL NHLBI NIH HHS; R35 HL155318 United States HL NHLBI NIH HHS; R00 NS087096 United States NS NINDS NIH HHS; R01 HL135242 United States HL NHLBI NIH HHS; R01 HL159010 United States HL NHLBI NIH HHS
    • الرقم المعرف:
      0 (Cited4 protein, mouse)
      0 (Transcription Factors)
    • الموضوع:
      Date Created: 20220705 Date Completed: 20220706 Latest Revision: 20240831
    • الموضوع:
      20240831
    • الرقم المعرف:
      PMC9253017
    • الرقم المعرف:
      10.1038/s42003-022-03635-y
    • الرقم المعرف:
      35787681