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Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma.

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  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 101560169 Publication Model: eCollection Cited Medium: Print ISSN: 2042-8812 (Print) Linking ISSN: 20428812 NLM ISO Abbreviation: J Surg Case Rep Subsets: PubMed not MEDLINE
    • بيانات النشر:
      Publication: 2013- : Oxford : Oxford University Press
      Original Publication: 2010-2012: Halesowen, UK : JSCR Publishing Limited
    • نبذة مختصرة :
      Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma is a variant of follicular dendritic cell neoplasm most often arising in the liver or spleen. Two histological patterns can be identified in this variant, namely a granulomatous and an eosinophil-rich one. We present the case of a 69-year-old woman with a splenic mass. After being removed, the mass was gray-whitish with an area of necrosis. Histology showed a diffuse distribution of epithelioid granulomas in a background of a dense lymphoplasmacytic infiltrate. Rare atypical cells EBV+ and CD21+ were present in the intergranulomatous areas. Differential diagnosis for the granulomatous type EBV+ inflammatory follicular dendritic cell sarcoma includes infection, sarcoidosis, inflammatory myofibroblastic tumor, T cell lymphoma and vasculitis. The origin of this neoplasm is the follicular dendritic cell, and, due to its similarities with a myofibroblast, differential diagnosis can be challenging. Immunohistochemistry for dendritic markers and in situ hybridization for EBER remain diagnostic keys.
      (Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022.)
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    • الموضوع:
      Date Created: 20220509 Latest Revision: 20230916
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC9071999
    • الرقم المعرف:
      10.1093/jscr/rjac034
    • الرقم المعرف:
      35531436