The Effect of Flowable Composite Resins on Periodontal Health, Cytokine Levels, and Immunoglobulins.

Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Publication: 2024- : [Hoboken, NJ] : Wiley
Original Publication: New York, NY : Hindawi Pub. Co.

Composite Resins* ; Dental Restoration, Permanent*; Cytokines ; Fluorides ; Gingival Crevicular Fluid ; Humans ; Immunoglobulin A ; Immunoglobulin M ; Interleukin-10 ; Interleukin-1beta ; Interleukins ; Osteoprotegerin ; Periodontitis/immunology ; Periodontitis/therapy ; Tooth Cervix

Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this article.
Objective: This study investigated the effects of flowable resin composites (FCR) on the restoration of noncarious cervical lesions (NCCL) and their impact on periodontal tissues.
Materials and Methods: 30 periodontally healthy patients were assigned into three groups randomly; group VF: self-adhering FCR, group NF: fluoride-releasing FCR, and group SF: microhybrid FCR. Gingival crevicular fluid (GCF) volume levels of osteoprotegerin (OPG), immunoglobulins (IgA, IgM), and interleukins (IL-1, IL-1 β , and IL-10) in GCF were analyzed with ELISA tests. Clinical success rates were evaluated using USPHS criteria during the 12-month follow-up.
Results: The GCF volume was increased mostly in group SF (1.34 ± 0.09  μ l). While the titer of interleukin was increased in all groups, higher increases were observed in IL-1 and IL-1 β in group NF (170.78 pg/ml and 39.35 pg/ml). Increased IL-10 was observed in group VF (14.33 ± 0.85 pg/ml). IgA levels varied partially among all groups ( p > 0.05), and even IgM levels were elevated immediately after the restoration process but returned to normal on the 28th day ( p < 0.05). Group NF failed in most of the USPHS criteria, while the material group VF and group SF presented acceptable results except in the marginal adaptation criterion ( p < 0.05).
Conclusions: Clinical efficacy of self-adhering FCR was found the best for restoration of NCCL while fluoride-releasing FCR stimulated the periodontal response and had negative effects on GCF volume, cytokine, and immunoglobulin levels.
(Copyright © 2022 Cem Peskersoy et al.)

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0 (Composite Resins)
0 (Cytokines)
0 (IL1B protein, human)
0 (Immunoglobulin A)
0 (Immunoglobulin M)
0 (Interleukin-1beta)
0 (Interleukins)
0 (Osteoprotegerin)
0 (TNFRSF11B protein, human)
0 (flowable hybrid composite)
130068-27-8 (Interleukin-10)
Q80VPU408O (Fluorides)

Date Created: 20220503 Date Completed: 20220504 Latest Revision: 20220716

20250114

PMC9056215

10.1155/2022/6476597

35502340