Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Aging*/genetics ; Cellular Senescence*/genetics; Animals ; Biomarkers ; Cell Cycle Checkpoints ; DNA Damage

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. It has many endogenous and exogenous inducers, and is closely connected with age, age-related pathologies, DNA damage, degenerative disorders, tumor suppression and activation, wound healing, and tissue repair. However, the literature is replete with contradictory findings concerning its triggering mechanisms, specific biomarkers, and detection protocols. This may be partly due to the wide range of cellular and in vivo animal or human models of accelerated aging that have been used to study senescence and test senolytic drugs. This review summarizes recent findings concerning senescence, presents some widely used cellular and animal senescence models, and briefly describes the best-known senolytic agents.

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LM2018133 Ministry of School, Education, Youth and Sports of the Czech Republic; CZ.02.1.01/0.0/0.0/16_019/0000868 Ministry of School, Education, Youth and Sports of the Czech Republic; TE02000058 Technological agency of the Czech Republic; IGA_LF_2021_036 Palacky University in Olomouc

Keywords: aging; cellular model; mouse model; senescence; senolytics

0 (Biomarkers)

Date Created: 20220423 Date Completed: 20220426 Latest Revision: 20220716

20231215

PMC9028163

10.3390/ijms23084168

35456986