Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- معلومة اضافية
- المصدر:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI, c1995-
- الموضوع:
- نبذة مختصرة :
Proteasome inhibitors have shown relevant clinical activity in several hematological malignancies, namely in multiple myeloma and mantle cell lymphoma, improving patient outcomes such as survival and quality of life, when compared with other therapies. However, initial response to the therapy is a challenge as most patients show an innate resistance to proteasome inhibitors, and those that respond to the therapy usually develop late relapses suggesting the development of acquired resistance. The mechanisms of resistance to proteasome inhibition are still controversial and scarce in the literature. In this review, we discuss the development of proteasome inhibitors and the mechanisms of innate and acquired resistance to their activity-a major challenge in preclinical and clinical therapeutics. An improved understanding of these mechanisms is crucial to guiding the design of new and more effective drugs to tackle these devastating diseases. In addition, we provide a comprehensive overview of proteasome inhibitors used in combination with other chemotherapeutic agents, as this is a key strategy to combat resistance.
- References:
Physiol Rev. 2002 Apr;82(2):373-428. (PMID: 11917093)
Front Chem. 2014 May 01;2:20. (PMID: 24822174)
Int J Lab Hematol. 2010 Feb;32(1 Pt 1):e123-31. (PMID: 19254348)
Am J Hematol. 2021 Jun 1;96(6):708-718. (PMID: 33755235)
Nat Rev Clin Oncol. 2017 Jul;14(7):417-433. (PMID: 28117417)
Structure. 2006 Mar;14(3):451-6. (PMID: 16531229)
J Med Chem. 2010 Sep 9;53(17):6511-5. (PMID: 20687609)
Eur J Med Chem. 2017 Jan 5;125:925-939. (PMID: 27769033)
Biomark Res. 2013 Mar 01;1(1):13. (PMID: 24252210)
Mol Cell Oncol. 2014 Dec 01;2(2):e974463. (PMID: 27308423)
Structure. 2015 Feb 3;23(2):407-17. (PMID: 25599643)
Biochim Biophys Acta. 2011 Feb;1809(2):67-79. (PMID: 20800708)
Clin Cancer Res. 2016 Sep 15;22(18):4559-66. (PMID: 27117181)
Eur J Med Chem. 2006 Aug;41(8):978-84. (PMID: 16713026)
Br J Haematol. 2019 Aug;186(4):549-560. (PMID: 31124580)
Nature. 2002 Sep 26;419(6905):403-7. (PMID: 12353037)
Cancer Chemother Pharmacol. 2015 Feb;75(2):281-91. (PMID: 25477008)
Clin Cancer Res. 2008 Jun 1;14(11):3503-13. (PMID: 18519783)
Leukemia. 2009 Nov;23(11):2181-3. (PMID: 19516276)
Blood. 2012 Oct 4;120(14):2817-25. (PMID: 22833546)
Br J Haematol. 2012 Sep;158(6):739-48. (PMID: 22845873)
Leukemia. 2014 Jul;28(7):1529-36. (PMID: 24429497)
Am J Hematol. 2013 Apr;88(4):265-72. (PMID: 23475625)
Am J Hematol. 2021 Jul 1;96(7):854-871. (PMID: 33725367)
J Exp Pharmacol. 2021 Mar 09;13:245-264. (PMID: 33727866)
J Clin Invest. 2012 Oct;122(10):3456-63. (PMID: 23023717)
J Antibiot (Tokyo). 2000 Jan;53(1):81-3. (PMID: 10724015)
Mol Pharmacol. 2014 Jul;86(1):12-9. (PMID: 24737138)
Blood. 2006 Nov 15;108(10):3441-9. (PMID: 16728695)
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6507-12. (PMID: 19359491)
Am J Hematol. 2021 Sep 1;96(9):1120-1130. (PMID: 34062004)
Clin Cancer Res. 2008 Mar 15;14(6):1649-57. (PMID: 18347166)
Oncotarget. 2016 Nov 22;7(47):77622-77634. (PMID: 27769058)
Exp Hematol. 2011 Dec;39(12):1117-8. (PMID: 21920470)
Bioorg Med Chem. 2009 Aug 1;17(15):5535-40. (PMID: 19577931)
J Mol Biol. 2001 Aug 17;311(3):543-8. (PMID: 11493007)
Cancers (Basel). 2020 Jun 12;12(6):. (PMID: 32545704)
J Natl Cancer Inst. 2010 Jul 21;102(14):1069-82. (PMID: 20505154)
J Hematol Oncol. 2021 Apr 13;14(1):59. (PMID: 33849608)
Blood. 2011 Jan 6;117(1):26-38. (PMID: 20940415)
Clin Cancer Res. 2013 May 1;19(9):2551-61. (PMID: 23549871)
Clin Lymphoma Myeloma Leuk. 2017 Nov;17(11):734-742. (PMID: 28733196)
Biochim Biophys Acta. 2011 Feb;1809(2):150-5. (PMID: 21184853)
Curr Cancer Drug Targets. 2011 Mar;11(3):239-53. (PMID: 21247388)
Eur J Cancer. 2013 Jan;49(2):290-6. (PMID: 23058787)
Invest New Drugs. 2012 Dec;30(6):2303-17. (PMID: 22080430)
Leukemia. 2010 Aug;24(8):1506-12. (PMID: 20555361)
Chem Biol. 2001 Aug;8(8):739-58. (PMID: 11514224)
Blood. 2018 Dec 13;132(24):2546-2554. (PMID: 30352784)
Biochem Pharmacol. 2012 Jan 15;83(2):207-17. (PMID: 22027222)
Leuk Res. 2006 Feb;30(2):240-1. (PMID: 16081156)
Chem Biol. 2002 May;9(5):655-62. (PMID: 12031672)
Leukemia. 2018 Feb;32(2):391-401. (PMID: 28676669)
Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8708-20. (PMID: 22711561)
Exp Hematol Oncol. 2013 Jan 10;2(1):2. (PMID: 23305345)
Cancer Chemother Pharmacol. 2007 Jul;60(2):245-55. (PMID: 17096161)
Biochem Pharmacol. 2014 May 1;89(1):43-51. (PMID: 24552657)
Arzneimittelforschung. 2008;58(6):261-4. (PMID: 18677966)
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):2967-72. (PMID: 11248015)
J Enzyme Inhib Med Chem. 2013 Jun;28(3):560-4. (PMID: 22380778)
J Med Chem. 2005 Jul 28;48(15):5038-42. (PMID: 16033282)
Cancer Chemother Pharmacol. 2013 May;71(5):1357-68. (PMID: 23589314)
Blood. 2012 Nov 29;120(23):4513-6. (PMID: 23018640)
Leukemia. 2012 Apr;26(4):757-68. (PMID: 21941364)
Bioorg Med Chem Lett. 2009 Jun 15;19(12):3220-4. (PMID: 19428245)
J Antibiot (Tokyo). 2012 Jun;65(6):279-88. (PMID: 22511225)
Pharmaceuticals (Basel). 2017 Apr 11;10(2):. (PMID: 28398261)
Br J Haematol. 2016 Sep;174(5):711-20. (PMID: 27161872)
Annu Rev Med. 2006;57:33-47. (PMID: 16409135)
Drug Resist Updat. 2015 Jan;18:18-35. (PMID: 25670156)
Curr Cancer Drug Targets. 2014;14(6):517-36. (PMID: 25092212)
Curr Opin Pharmacol. 2008 Feb;8(1):90-5. (PMID: 17981502)
Am J Pathol. 2007 Aug;171(2):513-24. (PMID: 17620365)
Chem Biol. 2012 Jan 27;19(1):99-115. (PMID: 22284358)
Chem Rev. 2007 Mar;107(3):687-717. (PMID: 17316053)
Oncol Lett. 2017 Sep;14(3):3185-3192. (PMID: 28927064)
J Cell Biochem. 2008 Jan 1;103(1):270-83. (PMID: 17516511)
J Hematol Oncol. 2016 Sep 06;9(1):82. (PMID: 27599459)
Neurooncol Adv. 2021 Oct 02;3(1):vdab142. (PMID: 34729484)
J Med Chem. 2013 May 9;56(9):3689-700. (PMID: 23547757)
Bioorg Med Chem Lett. 2009 Apr 1;19(7):1966-9. (PMID: 19250821)
Mol Cancer Ther. 2011 Nov;10(11):2034-42. (PMID: 22072815)
PLoS One. 2011;6(12):e27996. (PMID: 22216088)
Blood. 2012 Oct 18;120(16):3260-70. (PMID: 22932796)
Structure. 2015 Feb 3;23(2):418-24. (PMID: 25599644)
Exp Hematol. 2008 Oct;36(10):1278-84. (PMID: 18562081)
Annu Rev Pharmacol Toxicol. 2009;49:73-96. (PMID: 18834306)
Blood. 2007 Nov 1;110(9):3281-90. (PMID: 17591945)
Mol Pharmacol. 2006 Jul;70(1):426-33. (PMID: 16636137)
Neuron. 2003 Oct 9;40(2):427-46. (PMID: 14556719)
Leuk Res. 2012 Feb;36(2):212-8. (PMID: 21978467)
J Med Chem. 2012 Dec 13;55(23):10317-27. (PMID: 22978849)
J Antibiot (Tokyo). 2000 Feb;53(2):105-9. (PMID: 10805568)
J Biol Chem. 1998 Mar 6;273(10):5461-7. (PMID: 9488668)
Leukemia. 2009 Jun;23(6):1098-105. (PMID: 19225532)
Leuk Lymphoma. 2017 Aug;58(8):1872-1879. (PMID: 28140719)
J Hematol Oncol. 2014 Jan 13;7:7. (PMID: 24418325)
Science. 2016 Aug 5;353(6299):594-8. (PMID: 27493187)
Biochem Pharmacol. 2004 Jan 15;67(2):227-34. (PMID: 14698035)
Exp Hematol. 2009 Jul;37(7):831-7. (PMID: 19426847)
Biochem Biophys Res Commun. 1981 Aug 14;101(3):814-22. (PMID: 7030330)
Biochemistry. 2012 Aug 28;51(34):6880-8. (PMID: 22870914)
Nat Prod Rep. 2011 Oct;28(11):1854-67. (PMID: 21904761)
J Cell Commun Signal. 2011 Jun;5(2):101-10. (PMID: 21484190)
Curr Top Med Chem. 2010;10(3):232-56. (PMID: 20166955)
Mol Pharm. 2012 Aug 6;9(8):2197-205. (PMID: 22734651)
Molecules. 2016 Jul 16;21(7):. (PMID: 27438821)
Br J Pharmacol. 2012 Jan;165(2):345-62. (PMID: 21827448)
Blood. 2008 Sep 15;112(6):2489-99. (PMID: 18565852)
J Org Chem. 2000 Feb 25;65(4):990-5. (PMID: 10814045)
Cancer Res. 2003 Oct 1;63(19):6174-7. (PMID: 14559800)
Bioorg Med Chem Lett. 2008 Mar 15;18(6):1849-54. (PMID: 18294845)
J Med Chem. 2018 Nov 21;61(22):10299-10309. (PMID: 30365892)
J Natl Cancer Inst. 2011 Jul 6;103(13):1007-17. (PMID: 21606441)
J Med Chem. 2004 Mar 11;47(6):1587-90. (PMID: 14998343)
Haematologica. 2013 Dec;98(12):1896-904. (PMID: 24056819)
Biochem Biophys Res Commun. 2007 Sep 21;361(2):549-54. (PMID: 17662692)
Angew Chem Int Ed Engl. 2011 Jan 10;50(2):542-4. (PMID: 21154547)
Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1679-83. (PMID: 24403024)
Annu Rev Biochem. 1998;67:425-79. (PMID: 9759494)
Curr Opin Chem Biol. 2008 Aug;12(4):434-40. (PMID: 18656549)
J Pharmacol Exp Ther. 2012 Apr;341(1):174-82. (PMID: 22235146)
Lancet. 2020 Nov 14;396(10262):1563-1573. (PMID: 33189178)
Nat Med. 2021 Mar;27(3):491-503. (PMID: 33619369)
- Contributed Indexing:
Keywords: acquired resistance; cancer; innate resistance; mechanisms of resistance; multiple myeloma; proteasome inhibitors; ubiquitin–proteasome pathway
- الرقم المعرف:
0 (Antineoplastic Agents)
0 (Proteasome Inhibitors)
69G8BD63PP (Bortezomib)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
- الموضوع:
Date Created: 20220412 Date Completed: 20220413 Latest Revision: 20220423
- الموضوع:
20240628
- الرقم المعرف:
PMC9000344
- الرقم المعرف:
10.3390/molecules27072201
- الرقم المعرف:
35408601
No Comments.