Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

The benefits of grape seed extract in neurological disorders and brain aging.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2016- : Abingdon : Taylor & Francis
      Original Publication: [Amsterdam?] : Harwood Academic Publishers : Overseas Publishers Association [distributor], c1998-
    • الموضوع:
      Grape Seed Extract*/therapeutic use ; Nervous System Diseases*/drug therapy ; Vitis* ; Proanthocyanidins*/pharmacology ; Proanthocyanidins*/therapeutic use; Humans ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Polyphenols/therapeutic use ; Brain ; Aging ; Seeds
    • نبذة مختصرة :
      Common neurological disorders, including neurodegenerative diseases, stroke, epilepsy, autism and psychiatric disorders, affect many people worldwide and threaten their lives and health by inducing movement disorders, behavioral disorders, or a combination of both. Oxidative stress and neuroinflammation play a central role in neuronal damage and neurological diseases induction and progression. In addition, protein homeostasis (proteostasis) impairment occurs in many neurodegenerative diseases, which plays a critical role in the progression of the pathology. Grape seed contains several flavonoids and non-flavonoids and exerts potent antioxidant and anti-inflammatory effects. In addition, polyphenols and flavanols can maintain cellular proteostasis. Since impaired proteostasis is closely involved in all amyloid diseases, particularly neurodegenerative diseases, grape seeds extract can be a valuable therapeutic agent. Therefore, this review discusses the protective and therapeutic mechanisms of grape seed against neurological disorders and, in the end, links GSE to microRNAs as future therapeutic developments.
    • Contributed Indexing:
      Keywords: Grape seed; autism spectrum disorder; brain ageing‌; cerebral ischemia; epilepsy; microRNAs; neurodegeneration; proanthocyanidins‌; ‌gallic acid
    • الرقم المعرف:
      0 (Grape Seed Extract)
      0 (Antioxidants)
      0 (Polyphenols)
      0 (Proanthocyanidins)
    • الموضوع:
      Date Created: 20220328 Date Completed: 20230324 Latest Revision: 20230324
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1080/1028415X.2022.2051954
    • الرقم المعرف:
      35343876