Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Golgi Apparatus*/metabolism ; Membrane Proteins*/metabolism; Homeostasis ; Protein Transport ; Proteolysis

The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation. Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD). Here, we review recent discoveries in these mechanisms, highlighting the role of the Golgi in maintaining cellular homeostasis.

J Cell Sci. 2018 Sep 7;131(17):. (PMID: 30111579)
J Cell Sci. 2006 Sep 15;119(Pt 18):3888-900. (PMID: 16940348)
Nature. 2009 Jun 25;459(7250):1085-90. (PMID: 19553991)
EMBO Rep. 2018 Apr;19(4):. (PMID: 29437695)
J Cell Sci. 2012 Apr 1;125(Pt 7):1706-15. (PMID: 22328508)
Biochem Biophys Res Commun. 1998 Jan 26;242(3):673-9. (PMID: 9464276)
Mol Biol Cell. 2012 May;23(10):1860-73. (PMID: 22456507)
Annu Rev Cell Dev Biol. 2019 Oct 6;35:111-129. (PMID: 31340125)
J Biol Chem. 2003 May 23;278(21):18922-9. (PMID: 12754269)
Genes (Basel). 2020 May 18;11(5):. (PMID: 32443488)
Science. 2019 Nov 15;366(6467):818-822. (PMID: 31727826)
Curr Opin Cell Biol. 2011 Aug;23(4):483-91. (PMID: 21571517)
J Cell Biol. 2001 Oct 29;155(3):355-68. (PMID: 11673477)
Life Sci. 2020 Jul 15;253:117700. (PMID: 32335164)
Nat Cell Biol. 2002 Feb;4(2):117-23. (PMID: 11788821)
Cell Cycle. 2012 Dec 15;11(24):4613-25. (PMID: 23187805)
Autophagy. 2019 Oct;15(10):1774-1786. (PMID: 30957628)
Dev Cell. 2004 Jan;6(1):79-90. (PMID: 14723849)
J Cell Biol. 2021 Oct 4;220(10):. (PMID: 34473204)
Biochem J. 1993 Feb 15;290 ( Pt 1):21-6. (PMID: 8439291)
J Biol Chem. 1996 Nov 1;271(44):27645-51. (PMID: 8910354)
Exp Cell Res. 2014 Oct 15;328(1):1-19. (PMID: 25088255)
J Cell Biol. 2019 May 6;218(5):1634-1652. (PMID: 30917996)
Nat Rev Mol Cell Biol. 2019 Jun;20(6):368-383. (PMID: 30940912)
Biochem Mol Biol J. 2015;1(1):. (PMID: 27064441)
Cell Signal. 2017 May;33:98-106. (PMID: 28214587)
Mol Cell. 2011 Apr 22;42(2):160-71. (PMID: 21504829)
Mol Biol Cell. 2003 Jul;14(7):2756-67. (PMID: 12857862)
J Cell Biol. 1994 May;125(3):573-82. (PMID: 7909812)
EMBO J. 2016 Sep 15;35(18):1991-2007. (PMID: 27511903)
Cell Death Dis. 2016 Aug 11;7(8):e2330. (PMID: 27512951)
Cell Death Differ. 2009 Jul;16(7):956-65. (PMID: 19373247)
J Cell Biol. 2010 Jan 11;188(1):101-14. (PMID: 20065092)
J Cell Sci. 2011 Feb 1;124(Pt 3):469-82. (PMID: 21242315)
Biochem Biophys Res Commun. 2015 Jan 2;456(1):275-81. (PMID: 25436429)
Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(6):378-385. (PMID: 28603209)
Essays Biochem. 2013;55:51-64. (PMID: 24070471)
J Cell Sci. 2017 Jul 15;130(14):2251-2265. (PMID: 28536105)
J Cell Biol. 2019 Oct 7;218(10):3171-3187. (PMID: 31537714)
FEBS Lett. 2019 Sep;593(17):2466-2487. (PMID: 31381138)
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364. (PMID: 29618831)
Trends Biochem Sci. 2020 Jun;45(6):484-496. (PMID: 32307224)
J Biol Chem. 2001 Jun 29;276(26):23296-303. (PMID: 11316816)
J Biol Chem. 1991 Jul 5;266(19):12568-73. (PMID: 1712024)
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6. (PMID: 19926846)
Traffic. 2003 Mar;4(3):153-61. (PMID: 12656988)
PLoS Biol. 2011 May;9(5):e1001060. (PMID: 21572988)
Nature. 2009 Oct 1;461(7264):654-8. (PMID: 19794493)
Sci Rep. 2017 Feb 27;7:43207. (PMID: 28240221)
Mol Biol Cell. 2010 Apr 1;21(7):1153-65. (PMID: 20130083)
Mol Cell. 2015 Dec 17;60(6):899-913. (PMID: 26687599)
Trends Cell Biol. 2020 May;30(5):384-398. (PMID: 32302550)
Methods Mol Biol. 2016;1459:3-29. (PMID: 27665548)
Cell Death Differ. 2014 Mar;21(3):348-58. (PMID: 24440914)
Mol Biol Cell. 2008 Jul;19(7):2916-25. (PMID: 18448665)
J Biol Chem. 1994 Nov 25;269(47):29363-6. (PMID: 7961911)
EMBO J. 2005 Jul 20;24(14):2524-32. (PMID: 15973437)
J Cell Biol. 2010 Jan 25;188(2):237-51. (PMID: 20083603)
Curr Biol. 2018 Apr 23;28(8):R498-R511. (PMID: 29689233)
J Biol Chem. 2003 Feb 7;278(6):4216-26. (PMID: 12446665)
Int Rev Cell Mol Biol. 2015;315:1-22. (PMID: 25708460)
Autophagy. 2016 Oct 2;12(10):1721-1737. (PMID: 27462928)
Mol Cell. 2018 Aug 2;71(3):443-457. (PMID: 30075143)
Cell Res. 2017 Feb;27(2):184-201. (PMID: 27934868)
Cell. 1997 May 2;89(3):445-55. (PMID: 9150144)
Cell Discov. 2020 May 26;6(1):32. (PMID: 32509328)
J Biol Chem. 2004 Apr 9;279(15):15289-97. (PMID: 14744871)
EMBO J. 2016 Feb 1;35(3):281-301. (PMID: 26711178)
J Cell Biol. 2013 Jul 22;202(2):331-49. (PMID: 23878278)
FEBS Lett. 2005 Aug 15;579(20):4226-34. (PMID: 16081076)
Cancer Metastasis Rev. 2012 Dec;31(3-4):501-18. (PMID: 22699311)
Traffic. 2002 Nov;3(11):771-80. (PMID: 12383343)
Endocrinology. 2018 Nov 1;159(11):3674-3688. (PMID: 30215699)
J Cell Biol. 2020 Sep 7;219(9):. (PMID: 32573693)
EMBO J. 2016 Mar 1;35(5):496-514. (PMID: 26834238)
Cell. 2012 Dec 7;151(6):1163-7. (PMID: 23217703)
FEBS J. 2021 Jan;288(1):36-55. (PMID: 32542850)
Mol Biol Cell. 2007 Feb;18(2):455-63. (PMID: 17108324)
J Cell Biol. 2021 Jan 4;220(1):. (PMID: 33301566)
Protein J. 2019 Jun;38(3):317-329. (PMID: 31004255)
Physiol Rev. 2011 Jan;91(1):119-49. (PMID: 21248164)
Sci Rep. 2016 Mar 18;6:23326. (PMID: 26987296)
J Cell Biol. 2010 Sep 20;190(6):1005-22. (PMID: 20855505)
Cell. 2009 Oct 16;139(2):337-51. (PMID: 19837035)
Semin Cell Dev Biol. 2015 May;41:99-109. (PMID: 25460542)
Nature. 1991 Aug 1;352(6334):441-4. (PMID: 1861723)
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7015-20. (PMID: 26038556)
Mol Cell. 2020 Feb 6;77(3):618-632.e5. (PMID: 31806350)
Cancer J Sci Am. 1996 Jan-Feb;2(1):52-8. (PMID: 9166499)
J Cell Biol. 2002 Apr 29;157(3):405-15. (PMID: 11980916)
EMBO J. 2016 Nov 2;35(21):2332-2349. (PMID: 27655872)
Dev Cell. 2019 Apr 8;49(1):130-144.e6. (PMID: 30827897)
Cold Spring Harb Perspect Biol. 2011 Apr 01;3(4):. (PMID: 21441588)
EMBO J. 2021 Feb 1;40(3):e104705. (PMID: 33438778)
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):346-351. (PMID: 28028212)
Dev Cell. 2018 Apr 23;45(2):245-261.e6. (PMID: 29689198)
Cell Biosci. 2021 Feb 8;11(1):35. (PMID: 33557950)
Int Rev Cell Mol Biol. 2011;292:197-280. (PMID: 22078962)
FEBS Lett. 2019 Sep;593(17):2289-2305. (PMID: 31378930)
Biol Cell. 2011 Jul;103(7):333-50. (PMID: 21545355)
Eur J Cell Biol. 1998 Mar;75(3):223-31. (PMID: 9587053)
Mol Biol Cell. 2004 Dec;15(12):5420-30. (PMID: 15456905)
Mol Biol Cell. 2019 Aug 1;30(17):2296-2308. (PMID: 31166830)
Sci Rep. 2020 Oct 6;10(1):16604. (PMID: 33024151)
Cell Signal. 2015 Dec;27(12):2444-51. (PMID: 26327583)
Dev Cell. 2019 Sep 9;50(5):573-585.e5. (PMID: 31231041)
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10697-E10706. (PMID: 29180427)
Int J Mol Sci. 2019 Aug 12;20(16):. (PMID: 31408960)
Autophagy. 2016 Jul 2;12(7):1212-3. (PMID: 27171758)
Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25. (PMID: 19603039)
PLoS One. 2015 Apr 20;10(3):e0122083. (PMID: 25894744)
Mol Biol Cell. 1999 Jul;10(7):2407-23. (PMID: 10397773)
Cell Rep. 2015 Sep 22;12(11):1876-86. (PMID: 26344761)
EMBO J. 2019 Aug 1;38(15):e101433. (PMID: 31368600)
Nat Rev Mol Cell Biol. 2001 Feb;2(2):107-17. (PMID: 11252952)
Biochim Biophys Acta. 1998 Aug 14;1404(1-2):9-31. (PMID: 9714710)
Nat Commun. 2020 Jan 21;11(1):409. (PMID: 31964869)
Front Physiol. 2017 Jan 20;8:5. (PMID: 28163686)
Exp Cell Res. 2017 Mar 15;352(2):304-312. (PMID: 28223137)
Nat Commun. 2020 Apr 9;11(1):1754. (PMID: 32273498)
Traffic. 2010 Sep;11(9):1246-61. (PMID: 20545908)
PLoS One. 2017 Apr 6;12(4):e0173924. (PMID: 28384259)
EMBO J. 1999 Sep 15;18(18):4949-60. (PMID: 10487747)
Cell Struct Funct. 2003 Feb;28(1):49-54. (PMID: 12655150)
Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8763-8768. (PMID: 30111543)
Mol Biol Cell. 2008 May;19(5):2092-100. (PMID: 18321988)
iScience. 2018 Nov 30;9:382-398. (PMID: 30466064)
Cells. 2019 Jul 19;8(7):. (PMID: 31331075)
Tissue Cell. 2017 Apr;49(2 Pt A):133-140. (PMID: 27894594)
J Biol Chem. 1998 Dec 11;273(50):33273-8. (PMID: 9837899)
J Cell Sci. 2016 Oct 15;129(20):3781-3791. (PMID: 27587839)
EMBO J. 1993 Feb;12(2):677-82. (PMID: 8440258)
Autophagy. 2021 Sep;17(9):2290-2304. (PMID: 32960676)
J Cell Sci. 2018 Feb 8;131(3):. (PMID: 29361552)
Mol Neurobiol. 2016 Mar;53(2):1377-1385. (PMID: 25633094)
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28080-28091. (PMID: 33106423)
Cell. 1997 Oct 17;91(2):253-62. (PMID: 9346242)
Genes Cells. 2009 May;14(5):525-38. (PMID: 19371383)
EMBO Rep. 2014 Apr;15(4):392-401. (PMID: 24603492)
Mol Cell. 2021 Aug 19;81(16):3275-3293.e12. (PMID: 34245671)
Essays Biochem. 2017 Dec 12;61(6):609-624. (PMID: 29233872)
J Cell Biol. 2017 Jul 3;216(7):1937-1947. (PMID: 28483915)
Biochem J. 2019 Aug 28;476(16):2321-2346. (PMID: 31462439)
J Cell Biol. 2004 Apr;165(1):41-52. (PMID: 15078901)
Biol Cell. 2018 Jan;110(1):1-5. (PMID: 28990689)
EMBO J. 2011 Nov 08;30(23):4701-11. (PMID: 22068051)
J Cell Biol. 2002 Jul 8;158(1):91-101. (PMID: 12105183)
Autophagy. 2011 Jan;7(1):61-73. (PMID: 21068542)
J Lipid Res. 2019 Feb;60(2):269-275. (PMID: 30266835)
Cells. 2019 Dec 17;8(12):. (PMID: 31861136)
Front Cell Dev Biol. 2016 Apr 18;4:28. (PMID: 27148530)

Keywords: EGAD; GARD; GOMED; Golgi; autophagy; proteasomal degradation; proteostasis

0 (Membrane Proteins)

Date Created: 20220310 Date Completed: 20220411 Latest Revision: 20220411

20250114

PMC8909885

10.3390/cells11050780

35269404