Reducing length of hospital stay with colchicine.

Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE

Original Publication: [Italy?] : Open Learning on Enteric Pathogens

COVID-19* ; Colchicine*/therapeutic use; Hospitalization ; Humans ; Intensive Care Units ; Length of Stay ; Retrospective Studies ; SARS-CoV-2

Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions. It has been argued that colchicine could be an appropriate treatment option in COVID-19 to control hyperinflammatory response. Here in this study, we aimed to investigate the impact of colchicine on outcomes of COVID-19 in our inpatient cohort.
Methodology: In this retrospective cohort study, hospitalized COVID-19 patients were investigated. Demographics, comorbidities, COVID-19 symptoms, laboratory findings on admission and discharge, baseline and seventh day oxygenation status, rates of mortality, intensive care unit admission, administration of other anti-inflammatory treatments and length of hospital stay were compared between patients who received standard of care medications and who received colchicine additionally.
Results: Three hundred and thirty-six patients were included in the study (171 standard of care, 165 standard of care plus colchicine). The median length of hospital stay in colchicine group was significantly shorter. Rates of admission to intensive care unit, anti-inflammatory treatment administration and mortality did not differentiate between standard of care and colchicine groups. However, reduced rates of mortality and ICU admission were observed in patients who received colchicine with a dose of 1 mg/day when compared to patients who received 0.5 mg/day.
Conclusions: Our study demonstrated that COVID-19 patients who received colchicine in addition to standard of care had shorter hospital stay. Our results further support the use of colchicine in treatment of COVID-19, particularly with a dose of 1 mg/day.
Competing Interests: No Conflict of Interest is declared
(Copyright (c) 2022 ozlem Karakas, Abdulsamet Erden, Serdar Can Guven, Berkan Armagan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, Ihsan Ates, Ahmet Omma, Orhan Kucuksahin.)

Keywords: COVID-19; colchicine; hospitalization; mortality; outcome

SML2Y3J35T (Colchicine)

Date Created: 20220222 Date Completed: 20220225 Latest Revision: 20220225

20221213

10.3855/jidc.14924

35192522