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Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Biomed Central, 2008.
    • الموضوع:
      Genetic Predisposition to Disease* ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics; Cell Cycle Proteins/*genetics ; Nuclear Proteins/*genetics ; X-ray Repair Cross Complementing Protein 1/*genetics; Case-Control Studies ; Child ; DNA Repair/genetics ; DNA-Binding Proteins/genetics ; Genotype ; Humans ; Iran ; Polymorphism, Single Nucleotide
    • نبذة مختصرة :
      Objective: Acute lymphoblastic leukemia (ALL) is one of the most common cancers in children for which the exact pathogenesis is not yet known. Single-nucleotide variants (SNVs) in different DNA repair genes are reported to be associated with ALL risk. This study aimed to determine the association between XRCC1 (rs1799782) and NBN (rs1805794, rs709816) SNVs and childhood ALL risk in a sample of the Iranian population. Fifty children with ALL and 50 age- and sex-matched healthy children were included in this case-control study. Genotyping of the mentioned SNVs was done by high-resolution melting (HRM) analysis.
      Results: The prevalence of all three SNVs in XRCC1 and NBN genes did not differ between the patient and control groups, and these polymorphisms were not associated with childhood ALL risk (P > 0.05). HRM was a practical method for the detection of SNVs in XRCC1 and NBN genes. We found no significant association between XRCC1 (rs1799782) and NBN (rs1805794, rs709816) SNVs and childhood ALL risk.
      (© 2022. The Author(s).)
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    • Grant Information:
      96000989 Kerman University of Medical Sciences
    • Contributed Indexing:
      Keywords: Childhood acute lymphoblastic Leukemia; High-resolution melting analysis; NBN; Single nucleotide variants; XRCC1
    • الرقم المعرف:
      0 (Cell Cycle Proteins)
      0 (DNA-Binding Proteins)
      0 (NBN protein, human)
      0 (Nuclear Proteins)
      0 (X-ray Repair Cross Complementing Protein 1)
      0 (XRCC1 protein, human)
    • الموضوع:
      Date Created: 20220215 Date Completed: 20220216 Latest Revision: 20220531
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC8842869
    • الرقم المعرف:
      10.1186/s13104-022-05918-3
    • الرقم المعرف:
      35164849