Role of the mtDNA Mutations and Mitophagy in Inflammaging.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

DNA, Mitochondrial/*genetics ; Inflammation/*genetics ; Mitochondria/*genetics ; Mitophagy/*genetics ; Mutation/*genetics; Animals ; Humans ; Reactive Oxygen Species/metabolism

Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer's and Parkinson's, is also discussed.

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20-15-00337 Russian Science Foundation

Keywords: ageing; inflammaging; inflammation; mitophagy

0 (DNA, Mitochondrial)
0 (Reactive Oxygen Species)

Date Created: 20220215 Date Completed: 20220309 Latest Revision: 20220309

20221213

PMC8836173

10.3390/ijms23031323

35163247