Clinical and Translational Significance of Basophils in Patients with Cancer.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Hypersensitivity* ; Neoplasms*/metabolism; Basophils ; Cytokines/metabolism ; Humans ; Tumor Microenvironment

Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as histamine, granzyme B, and cytokines are stored in dense cytoplasmic granules, ready to be secreted in response to a range of immune stimuli. Basophils play key roles in eliciting potent effector functions in allergic diseases and type 1 hypersensitivity. Beyond allergies, basophils can be recruited to tissues in chronic and autoimmune inflammation, and in response to parasitic, bacterial, and viral infections. While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several tumor types, basophils have received little attention in cancer. Here, we discuss the presence and functional significance of basophils in the circulation of cancer patients and in the tumor microenvironment (TME). Interrogating publicly available datasets, we conduct gene expression analyses to explore basophil signatures and associations with clinical outcomes in several cancers. Furthermore, we assess how basophils can be harnessed to predict hypersensitivity to cancer treatments and to monitor the desensitization of patients to oncology drugs, using assays such as the basophil activation test (BAT).

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C30122/A11527 United Kingdom CRUK_ Cancer Research UK; C10355/A15587 CR UK//NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre; MR/L023091/1 United Kingdom MRC_ Medical Research Council; SPF573 Guy's and St Thomas' Foundation Trust Charity Melanoma Special Fund; 147; KCL-BCN-Q3 United Kingdom BBC_ Breast Cancer Now; C604/A25135 Cancer Research UK King's Health Partners Centre at King's College London; IS-BRC-1215-20006 National Institute for Health Research Biomedical Research Centre based at Guy's and St Thom-as' NHS Foundation Trust and King's College London; C30122/A15774 United Kingdom CRUK_ Cancer Research UK

Keywords: IgE; allergooncology; anaphylaxis; basophil; basophil activation test (BAT); cancer; gene expression; immunotherapy; survival; type I hypersensitivity

0 (Cytokines)

Date Created: 20220215 Date Completed: 20220408 Latest Revision: 20220716

20250114

PMC8833920

10.3390/cells11030438

35159247