Infrared- and white-light retinal sensitivity in glaucomatous neuropathy.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Light* ; Slit Lamp Microscopy* ; Tomography, Optical Coherence* ; Visual Field Tests*; Glaucoma, Open-Angle/*diagnosis ; Optic Nerve/*diagnostic imaging ; Photophobia/*diagnosis ; Retina/*physiopathology; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Glaucoma, Open-Angle/physiopathology ; Humans ; Male ; Middle Aged ; Optic Nerve/physiopathology ; Photic Stimulation ; Photophobia/physiopathology ; Predictive Value of Tests ; Proof of Concept Study ; Visual Fields

Glaucoma causes irreversible neuropathy, which, untreated, may lead to blindness. In this case-control study, we measured two-photon infrared (IR) light sensitivity in glaucomatous eyes to propose a new method to quantify the visual loss. In total, 64 patients were recruited with an equal distribution between glaucoma and control groups. Retinal sensitivity to IR light was assessed using a two-photon excitation device. A fundus-driven microperimeter was used to measure retinal sensitivity to visible light. The retinal nerve fiber layer (RNFL) thickness was quantified automatically with optical coherence tomography. The IR sensitivity of glaucoma and control eyes differed significantly (P = .003): 9.8 (6.5 to 13.1) dB vs. 10.9 (8.2 to 13.0) dB. Although in the visible-light microperimetry, retinal sensitivity was decreased in glaucoma (17.0, range: 6.9 to 20.0 dB) compared to the controls (17.7, range: 11.6 to 20.0 dB), this difference did not reach the significance level. A significant thinning of the RNFL in the glaucoma group was observed (P < .001). IR sensitivity significantly correlated with the RNFL in three of the four assessed quadrants instead of only one in visible-light microperimetry. Although further research is needed, this proof-of-concept study suggests that IR-light sensitivity can be used to support the detection of glaucomatous neuropathy.
(© 2022. The Author(s).)

Surv Ophthalmol. 1989 Feb;33 Suppl:291-300. (PMID: 2655142)
Biomed Opt Express. 2020 Dec 17;12(1):462-479. (PMID: 33659083)
Transl Vis Sci Technol. 2017 Jul 13;6(4):7. (PMID: 28713647)
Invest Ophthalmol Vis Sci. 2012 Oct 09;53(11):7010-7. (PMID: 22952121)
J Cataract Refract Surg. 2015 Jul;41(7):1406-15. (PMID: 26287879)
Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8063-8. (PMID: 26720457)
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5445-54. (PMID: 25453064)
Ophthalmology. 2007 Oct;114(10):1810-5. (PMID: 17583352)
Behav Res Methods. 2009 Nov;41(4):1149-60. (PMID: 19897823)
Transl Vis Sci Technol. 2020 Jul 07;9(8):7. (PMID: 32855854)
J Glaucoma. 2011 Aug;20(6):383-7. (PMID: 20717050)
Am J Ophthalmol. 2004 Jun;137(6):988-92. (PMID: 15183781)
J Opt Soc Am. 1947 Jul;37(7):546-54. (PMID: 20256359)
Invest Ophthalmol Vis Sci. 2013 May 13;54(5):3417-25. (PMID: 23532529)
J Glaucoma. 2008 Mar;17(2):118-21. (PMID: 18344757)
JAMA Ophthalmol. 2021 May 1;139(5):526-541. (PMID: 33576772)
Eye (Lond). 2017 Mar;31(3):443-451. (PMID: 27834960)
Br J Ophthalmol. 2010 Jan;94(1):64-7. (PMID: 19692366)
Ophthalmology. 2014 Nov;121(11):2081-90. (PMID: 24974815)
Retina. 2021 Jun 1;41(6):1302-1308. (PMID: 33323904)
Prog Retin Eye Res. 2010 Jul;29(4):249-71. (PMID: 20226873)
Ophthalmic Res. 2013;49(4):192-8. (PMID: 23306647)
Transl Vis Sci Technol. 2021 Feb 5;10(2):11. (PMID: 34003895)
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6573-80. (PMID: 26567476)
Am J Ophthalmol. 2006 Jan;141(1):24-30. (PMID: 16386972)
Biomed Opt Express. 2019 Aug 09;10(9):4551-4567. (PMID: 31565509)
Br J Ophthalmol. 1977 Feb;61(2):107-13. (PMID: 843505)

Date Created: 20220205 Date Completed: 20220309 Latest Revision: 20220309

20221213

PMC8816930

10.1038/s41598-022-05718-6

35121766