Association of fasting blood glucose to high-density lipoprotein cholesterol ratio with short-term outcomes in patients with acute coronary syndrome.

Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2002-

Acute Coronary Syndrome/*blood ; Blood Glucose/*analysis ; Cholesterol, HDL/*blood; Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/mortality ; Female ; Humans ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/etiology ; Myocardial Infarction/mortality ; Risk Factors

Background: Biochemical markers are crucial for determining risk in coronary artery disease (CAD) patients; however, the relationship between fasting blood glucose to high-density lipoprotein cholesterol (FG/HDL-C) ratio and short-term outcomes in acute coronary syndrome (ACS) patients remains unknown. Therefore, we have investigated the relationship between the FG/HDL-C ratio and short-term outcomes in ACS patients.
Methods: We used data from a pragmatic, stepped-wedge, cluster-randomized clinical trial to perform a post hoc analysis. A total of 11,284 individuals with ACS were subdivided into quartiles according to their FG/HDL-C ratios. We used a multivariate logistic regression model, two-piecewise linear regression model, and generalized additive model (GAM) to evaluate the relationship between the FG/HDL-C ratio and short-term outcomes (major adverse cardiovascular events [MACEs] and cardiovascular [CV] death within 30 days).
Results: The FG/HDL-C ratio was remarkably linked to an enhanced risk of MACEs and CV death in individuals with ACS in the highest quartile (MACEs, odds ratio [OR]: 1.49; 95% confidence interval [CI], [1.11, 1.99]; P < 0.01; CV death, OR: 1.69; 95% CI, [1.01, 1.41]; P = 0.04). The GAM suggested that the relationship between the FG/HDL-C ratio and MACEs and CV death was non-linear. The two-piecewise linear regression model demonstrated that the threshold values were 3.02 and 3.00 for MACEs and CV death, respectively.
Conclusions: A higher FG/HDL-C ratio is associated with a higher risk of MACEs and CV death in patients with ACS.
(© 2022. The Author(s).)

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Keywords: Acute coronary syndrome; Cardiovascular death; Fasting blood glucose; High-density lipoprotein cholesterol; Major adverse cardiovascular events; Metabolic syndrome

0 (Blood Glucose)
0 (Cholesterol, HDL)

Date Created: 20220131 Date Completed: 20220328 Latest Revision: 20220328

20221213

PMC8802470

10.1186/s12944-021-01618-2

35094695