Moderate physical activity may not decrease the risk of cardiovascular disease in persistently overweight and obesity adults.

Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2003-

Cardiovascular Diseases*/epidemiology ; Exercise*/physiology ; Obesity*/epidemiology ; Overweight*/epidemiology; Adult ; Body Mass Index ; Humans ; Risk Assessment

Background: Body mass index (BMI) and physical activity (PA) has been documented to be associated with cardiovascular disease (CVD). However, the evidences regarding joint phenotypes of BMI and PA trajectories with risk for CVD and all-cause mortality are still limited.
Methods: Participants from the Kailuan Study, followed up during 2006-2019 were included, with primary outcomes of CVDs (myocardial infarction or stroke) and all-cause mortality. BMI and PA were repeatedly measured at least three times, and thus joint phenotypes trajectory groups were identified by group-based trajectory modeling. Cox proportional hazards models were used to examine the associations between trajectory groups and CVDs and all-cause mortality.
Results: Totally 88,141 (6 trajectories) and 89,736 participants (5 trajectories) were included in the final analyses relating trajectories to CVDs and all-cause mortality, respectively. Compared with persistent normal-weight with moderate PA group, participants were associated with increased risk of CVD in persistent overweight with moderate PA trajectory group (adjusted hazard ratio [aHR]: 1.31, 95% confidence interval [CI]: 1.22-1.41) and persistent obesity with moderate PA trajectory group (aHR: 1.55, 95% CI: 1.41-1.69). While the rising to overweight with moderate PA in normal-weight status with active PA (aHR: 0.72, 95% CI: 0.65-0.79), persistent overweight with moderate PA (aHR: 0.92, 95% CI: 0.87-0.97) and decline to normal-weight in overweight status with moderate PA (aHR: 0.73, 95% CI: 0.67-0.80) trajectories group were significantly associated with decreased all-cause mortality risk. The associations remained robust among stratifying by age and sex individuals and sensitive analysis.
Conclusions: The long-term trajectories analysis showed that moderate PA may not decrease the risk of CVD in persistently overweight and obesity adults.
(© 2022. The Author(s).)

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NSFC 81561128020-NHMRC APP1112767 the China-Australian Collaborative Grant; 81561128020 the National Natural Science Foundational Research Fund

Keywords: All-cause mortality; Body mass index; Cardiovascular disease; Long-term trajectories; Physical activity

Date Created: 20220129 Date Completed: 20220318 Latest Revision: 20220531

20221213

PMC8796584

10.1186/s12967-021-03212-7

35090510