Severity Biomarkers in Puumala Hantavirus Infection.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Biomarkers* ; Puumala virus*/genetics; Hemorrhagic Fever with Renal Syndrome/*diagnosis; Acute Kidney Injury/virology ; Antibodies, Viral ; Cytokines/metabolism ; Endothelial Cells ; Europe ; Orthohantavirus/genetics ; Hantavirus Infections/diagnosis ; Hemorrhagic Fever with Renal Syndrome/virology ; Humans ; Thrombocytopenia

Annually, over 10,000 cases of hemorrhagic fever with renal syndrome (HFRS) are diagnosed in Europe. Puumala hantavirus (PUUV) causes most of the European HFRS cases. PUUV causes usually a relatively mild disease, which is rarely fatal. However, the severity of the infection varies greatly, and factors affecting the severity are mostly unrevealed. Host genes are known to have an effect. The typical clinical features in PUUV infection include acute kidney injury, thrombocytopenia, and increased vascular permeability. The primary target of hantavirus is the endothelium of the vessels of different organs. Although PUUV does not cause direct cytopathology of the endothelial cells, remarkable changes in both the barrier function of the endothelium and the function of the infected endothelial cells occur. Host immune or inflammatory mechanisms are probably important in the development of the capillary leakage. Several immunoinflammatory biomarkers have been studied in the context of assessing the severity of HFRS caused by PUUV. Most of them are not used in clinical practice, but the increasing knowledge about the biomarkers has elucidated the pathogenesis of PUUV infection.

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Keywords: Puumala virus; biomarker; hantavirus; hemorrhagic fever with renal syndrome

0 (Antibodies, Viral)
0 (Biomarkers)
0 (Cytokines)

Date Created: 20220122 Date Completed: 20220228 Latest Revision: 20221207

20231215

PMC8778356

10.3390/v14010045

35062248