Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Epigenesis, Genetic*; Anti-Bacterial Agents/*pharmacology ; Oils, Volatile/*pharmacology ; Plant Oils/*pharmacology; DNA Methylation ; Drug Resistance, Bacterial/drug effects ; Escherichia coli/drug effects ; Foeniculum/chemistry ; Foeniculum/genetics ; Italy ; Lamiaceae/chemistry ; Lamiaceae/genetics ; Microbial Sensitivity Tests ; Odorants ; Oils, Volatile/chemistry ; Origanum/chemistry ; Origanum/genetics ; Plant Oils/chemistry ; Plants/chemistry ; Taste

Natural compounds have historically had a wide application in nutrition. Recently, a fundamental role has been identified for essential oils extracted from aromatic plants for their nutritional, antimicrobial, and antioxidant properties, and as food preservatives. In the present study, essential oils (EOs) from ten aromatic plants grown in Calabria (Italy), used routinely to impart aroma and taste to food, were evaluated for their antibacterial activity. This activity was investigated against Escherichia coli strain JM109, and its derived antibiotic-resistant cells selected by growing the strain at low concentrations of ampicillin, ciprofloxacin, and gentamicin by measuring the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). Although all the essential oils showed bactericidal activity, those from Clinopodium nepeta , Origanum vulgare , and Foeniculum vulgare displayed the greatest inhibitory effects on the bacterial growth of all cell lines. It is plausible that the antibacterial activity is mediated by epigenetic modifications since the tested essential oils induce methylation both at adenine and cytosine residues in the genomes of most cell lines. This study contributes to a further characterization of the properties of essential oils by shedding new light on the molecular mechanisms that mediate these properties.

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Keywords: MBC; MIC; adenine methylation; antibiotic resistance; antimicrobial; cytosine methylation; essential oils; herbs; nutrition; spices

0 (Anti-Bacterial Agents)
0 (Oils, Volatile)
0 (Plant Oils)

Date Created: 20220121 Date Completed: 20220127 Latest Revision: 20220128

20240829

PMC8780331

10.3390/nu14020391

35057572