Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Determinants of severity among hospitalised COVID-19 patients: Hospital-based case-control study, India, 2020.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Hospitalization* ; SARS-CoV-2* ; Severity of Illness Index*; COVID-19/*blood ; COVID-19/*epidemiology; Adolescent ; Adult ; Age Factors ; C-Reactive Protein/analysis ; Case-Control Studies ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Hospitals ; Humans ; India/epidemiology ; Interleukin-6/blood ; L-Lactate Dehydrogenase/blood ; Male ; Middle Aged ; Procalcitonin/blood ; Risk Factors ; Young Adult
    • نبذة مختصرة :
      Background: Risk factors for the development of severe COVID-19 disease and death have been widely reported across several studies. Knowledge about the determinants of severe disease and mortality in the Indian context can guide early clinical management.
      Methods: We conducted a hospital-based case control study across nine sites in India to identify the determinants of severe and critical COVID-19 disease.
      Findings: We identified age above 60 years, duration before admission >5 days, chronic kidney disease, leucocytosis, prothrombin time > 14 sec, serum ferritin >250 ng/mL, d-dimer >0.5 ng/mL, pro-calcitonin >0.15 μg/L, fibrin degradation products >5 μg/mL, C-reactive protein >5 mg/L, lactate dehydrogenase >150 U/L, interleukin-6 >25 pg/mL, NLR ≥3, and deranged liver function, renal function and serum electrolytes as significant factors associated with severe COVID-19 disease.
      Interpretation: We have identified a set of parameters that can help in characterising severe COVID-19 cases in India. These parameters are part of routinely available investigations within Indian hospital settings, both public and private. Study findings have the potential to inform clinical management protocols and identify patients at high risk of severe outcomes at an early stage.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      JAMA. 2020 Apr 7;323(13):1239-1242. (PMID: 32091533)
      Intensive Care Med. 2020 May;46(5):837-840. (PMID: 32123994)
      Int J Public Health. 2020 Jun;65(5):533-546. (PMID: 32451563)
      BMJ. 2020 Mar 26;368:m1198. (PMID: 32217618)
      J Clin Med. 2020 Aug 04;9(8):. (PMID: 32759645)
      Signal Transduct Target Ther. 2020 Mar 27;5(1):33. (PMID: 32296069)
      Postgrad Med J. 2020 Nov 12;:. (PMID: 33184141)
      Int J Infect Dis. 2020 May;94:91-95. (PMID: 32173574)
      Diabetes Metab Syndr. 2020 Jul - Aug;14(4):535-545. (PMID: 32408118)
      J Clin Epidemiol. 1996 Dec;49(12):1373-9. (PMID: 8970487)
      BMJ. 2020 Apr 7;369:m1328. (PMID: 32265220)
      BMC Infect Dis. 2021 Jan 25;21(1):113. (PMID: 33494706)
      Am J Kidney Dis. 2021 Dec;78(6):804-815. (PMID: 34364906)
      JAMA. 2020 Apr 28;323(16):1545-1546. (PMID: 32167538)
      Lancet. 2020 Mar 28;395(10229):1033-1034. (PMID: 32192578)
      Rev Med Virol. 2020 Nov;30(6):1-9. (PMID: 32845568)
      Eur J Clin Invest. 2020 Oct;50(10):e13378. (PMID: 32860457)
      Clin Exp Med. 2020 Nov;20(4):493-506. (PMID: 32720223)
    • الرقم المعرف:
      0 (Fibrin Fibrinogen Degradation Products)
      0 (IL6 protein, human)
      0 (Interleukin-6)
      0 (Procalcitonin)
      0 (fibrin fragment D)
      9007-41-4 (C-Reactive Protein)
      EC 1.1.1.27 (L-Lactate Dehydrogenase)
    • الموضوع:
      Date Created: 20211229 Date Completed: 20220114 Latest Revision: 20220114
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC8716035
    • الرقم المعرف:
      10.1371/journal.pone.0261529
    • الرقم المعرف:
      34965276