The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Chronic Disease/*drug therapy ; Curcumin/*therapeutic use; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; Biological Availability ; Chronic Disease/prevention & control ; Curcumin/analogs & derivatives ; Curcumin/chemistry ; Humans ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use ; Nanotechnology ; Solubility

Curcumin is the primary polyphenol in turmeric's curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin's bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.

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Keywords: anti-inflammatory action; anticancer; antioxidant effect; nanocurcumin; neurodegenerative disease; solubility

0 (Anti-Bacterial Agents)
0 (Anti-Inflammatory Agents)
IT942ZTH98 (Curcumin)

Date Created: 20211210 Date Completed: 20220216 Latest Revision: 20230921

20230921

PMC8659038

10.3390/molecules26237109

34885693