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Rethinking Carbohydrate Intake and Time in Range in Children and Adolescents with Type 1 Diabetes.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • الموضوع:
      Time Factors*; Diabetes Mellitus, Type 1/*blood ; Dietary Carbohydrates/*analysis ; Eating/*physiology ; Glycemic Control/*statistics & numerical data; Adolescent ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Child ; Diabetes Mellitus, Type 1/diet therapy ; Diet/statistics & numerical data ; Diet Records ; Dietary Fiber/analysis ; Dietary Proteins/analysis ; Female ; Glycated Hemoglobin/analysis ; Humans ; Italy ; Logistic Models ; Male ; Postprandial Period/physiology
    • نبذة مختصرة :
      The aim of this study was to evaluate the association between macronutrient intake and time in range (TIR) of 70-180 mg/dL in children and adolescents with type 1 diabetes (T1D). A multi-center study recruited patients with T1D using continuous glucose monitoring (CGM) between January 2019 and January 2020 from centers across Italy. Diet intake was recorded using three-day weighed food diaries. Nutrients were evaluated as percentages of total intake. TIR was considered at target if the percentage of readings was higher than 70%. Clinical and nutritional factors associated with TIR at target were analyzed using multiple correspondence analysis and multiple logistic regression. Data from 197 participants (53% male, median age 11.6 years, median HbA1c 55.2 mmol/mol, median TIR 60%) were analyzed. Macronutrient intake was 45.9% carbohydrates, 16.9% protein, 37.3% fat, and 13.1 g/day fiber (median values). TIR > 70% was observed in 28% of participants; their diet contained more protein (17.6%, p = 0.015) and fiber (14.4 g/day, p = 0.031) than those not at target. The probability of having a TIR > 70% was significantly higher with 40-44% consumption of carbohydrates compared with 45-50% consumption of carbohydrates and with the use of a carbohydrate counting system. Based on these results, a five percent reduction in the percentage of carbohydrate intake can help children and adolescents with T1D achieve the goal of a TIR > 70%. Both a lower and higher percentage of carbohydrate intake appears to reduce the probability of reaching the target TIR > 70%. These results require validation in other populations before being used in clinical practice.
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    • Contributed Indexing:
      Keywords: children and adolescents; continuous glucose monitoring; macronutrients; multi-center observational study; time in range; type 1 diabetes
    • الرقم المعرف:
      0 (Blood Glucose)
      0 (Dietary Carbohydrates)
      0 (Dietary Fiber)
      0 (Dietary Proteins)
      0 (Glycated Hemoglobin A)
      0 (hemoglobin A1c protein, human)
    • الموضوع:
      Date Created: 20211127 Date Completed: 20211213 Latest Revision: 20221207
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC8624203
    • الرقم المعرف:
      10.3390/nu13113869
    • الرقم المعرف:
      34836124