Unravel the Local Complexity of Biological Environments by MALDI Mass Spectrometry Imaging.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Host Microbial Interactions* ; Lipid Metabolism* ; Metabolome*; Fungi/*metabolism ; Lipidomics/*methods ; Plants/*metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods; Animals ; Diagnostic Imaging/methods ; Humans ; Insecta/metabolism ; Nematoda/metabolism ; Peptides/metabolism ; Symbiosis

Classic metabolomic methods have proven to be very useful to study functional biology and variation in the chemical composition of different tissues. However, they do not provide any information in terms of spatial localization within fine structures. Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) does and reaches at best a spatial resolution of 0.25 μm depending on the laser setup, making it a very powerful tool to analyze the local complexity of biological samples at the cellular level. Here, we intend to give an overview of the diversity of the molecules and localizations analyzed using this method as well as to update on the latest adaptations made to circumvent the complexity of samples. MALDI MSI has been widely used in medical sciences and is now developing in research areas as diverse as entomology, microbiology, plant biology, and plant-microbe interactions, the rhizobia symbiosis being the most exhaustively described so far. Those are the fields of interest on which we will focus to demonstrate MALDI MSI strengths in characterizing the spatial distributions of metabolites, lipids, and peptides in relation to biological questions.

Nat Methods. 2017 Jan;14(1):57-60. (PMID: 27842059)
J Proteome Res. 2017 Aug 4;16(8):2993-3001. (PMID: 28648079)
J Am Soc Mass Spectrom. 2015 Jan;26(1):149-58. (PMID: 25323862)
ACS Chem Biol. 2017 Aug 18;12(8):1980-1985. (PMID: 28617577)
Anal Chem. 2016 Nov 1;88(21):10362-10367. (PMID: 27676129)
Chembiochem. 2010 Jun 14;11(9):1245-52. (PMID: 20486243)
J Am Soc Mass Spectrom. 2017 Mar;28(3):434-442. (PMID: 28050871)
Bioresour Technol. 2008 Jul;99(11):4544-50. (PMID: 17826983)
Front Plant Sci. 2019 Jul 19;10:845. (PMID: 31379891)
J Mass Spectrom. 2020 Dec;55(12):e4633. (PMID: 33043525)
Anal Chem. 2020 Sep 15;92(18):12126-12131. (PMID: 32786442)
J Proteome Res. 2016 Dec 2;15(12):4403-4411. (PMID: 27726374)
Anal Chem. 2019 Jul 2;91(13):8221-8228. (PMID: 31149814)
Anal Bioanal Chem. 2020 Apr;412(10):2277-2289. (PMID: 31879798)
ISME J. 2018 Sep;12(9):2335-2338. (PMID: 29899508)
Anal Chem. 2014 Oct 21;86(20):10071-7. (PMID: 25230319)
J Mass Spectrom. 2019 Jun;54(6):557-566. (PMID: 31038251)
Chempluschem. 2019 Sep;84(9):1338-1345. (PMID: 31944045)
Plant J. 2021 Jun;106(6):1791-1806. (PMID: 33797826)
J Am Soc Mass Spectrom. 2021 Jan 6;32(1):114-123. (PMID: 33280376)
J Proteome Res. 2014 Jun 6;13(6):3054-64. (PMID: 24742365)
Anal Chem. 2019 Feb 5;91(3):1980-1988. (PMID: 30605313)
PLoS One. 2015 Oct 20;10(10):e0139445. (PMID: 26485142)
Analyst. 2006 Sep;131(9):966-86. (PMID: 17047796)
Anal Chem. 2012 Feb 7;84(3):1557-64. (PMID: 22243218)
Chem Biol. 2014 Nov 20;21(11):1575-84. (PMID: 25457182)
Anal Chem. 2017 Jul 18;89(14):7493-7501. (PMID: 28613836)
Environ Microbiol. 2017 May;19(5):1822-1835. (PMID: 28109049)
Anal Bioanal Chem. 2021 Apr;413(10):2599-2617. (PMID: 33215311)
Front Plant Sci. 2018 Aug 28;9:1238. (PMID: 30210517)
Front Plant Sci. 2019 Jul 12;10:860. (PMID: 31354754)
Anal Chem. 2020 Oct 6;92(19):13084-13091. (PMID: 32668145)
Clin Chem Lab Med. 2020 Jun 25;58(6):914-929. (PMID: 31665113)
Nat Protoc. 2012 Apr 12;7(5):872-81. (PMID: 22498707)
ISME J. 2016 Sep;10(9):2317-30. (PMID: 26943626)
Anal Bioanal Chem. 2019 Feb;411(4):953-964. (PMID: 30565172)
J Mass Spectrom. 2000 Nov;35(11):1237-45. (PMID: 11114080)
Anal Bioanal Chem. 2016 Nov;408(27):7607-7615. (PMID: 27230625)
Plant J. 2012 Apr;70(1):81-95. (PMID: 22449044)
Mol Plant Microbe Interact. 2018 Oct;31(10):1048-1059. (PMID: 29663868)
Anal Chem. 2015 Nov 17;87(22):11309-16. (PMID: 26491885)
J Nat Prod. 2015 Jun 26;78(6):1231-42. (PMID: 25981198)
Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3874-3883. (PMID: 32015118)
Anal Bioanal Chem. 2015 Oct;407(25):7589-602. (PMID: 26310845)
Nutr Rev. 2009 Nov;67(11):615-23. (PMID: 19906248)
J Agric Food Chem. 2020 Jun 17;68(24):6770-6775. (PMID: 32437141)
Talanta. 2021 Jan 1;221:121453. (PMID: 33076076)
J Am Soc Mass Spectrom. 2015 Nov;26(11):1959-62. (PMID: 26297185)
Talanta. 2020 Mar 1;209:120557. (PMID: 31892065)
Anal Chem. 2020 Oct 20;92(20):14130-14138. (PMID: 32924439)
J Lipid Res. 2009 Apr;50 Suppl:S317-22. (PMID: 19050313)
Phytochemistry. 2015 Jul;115:161-70. (PMID: 25749617)
J Appl Microbiol. 2013 May;114(5):1300-10. (PMID: 23387377)
J Agric Food Chem. 2019 Dec 11;67(49):13470-13477. (PMID: 31334645)
J Agric Food Chem. 2017 Sep 6;65(35):7624-7628. (PMID: 28718648)
Plant J. 2013 Oct;76(1):138-50. (PMID: 23808562)
Anal Chem. 2021 Jul 20;93(28):9826-9834. (PMID: 34228922)
Anal Chem. 2010 Oct 15;82(20):8476-84. (PMID: 20853893)
Appl Microbiol Biotechnol. 2005 Oct;68(6):718-25. (PMID: 16160828)
Nat Prod Rep. 2020 Feb 26;37(2):150-162. (PMID: 31364647)
Ecotoxicol Environ Saf. 2020 Dec 1;205:111102. (PMID: 32836152)
Cell. 2007 Sep 7;130(5):784-95. (PMID: 17803903)
Biochim Biophys Acta. 2011 Nov;1811(11):807-17. (PMID: 21571093)
Plant J. 2013 Jul;75(1):130-145. (PMID: 23551619)
Anal Bioanal Chem. 2017 Feb;409(5):1221-1230. (PMID: 27873003)
J Am Soc Mass Spectrom. 2002 Jun;13(6):735-48. (PMID: 12056573)
Anal Chem. 2018 Aug 7;90(15):9272-9280. (PMID: 29975508)
J Nat Prod. 2018 Jul 27;81(7):1527-1533. (PMID: 29916245)
Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10530-10534. (PMID: 29787633)
Front Plant Sci. 2018 Sep 11;9:1296. (PMID: 30254654)
J Sep Sci. 2021 Sep;44(18):3462-3476. (PMID: 34245221)
Molecules. 2014 Jul 21;19(7):10587-600. (PMID: 25050857)
J Am Soc Mass Spectrom. 2014 Aug;25(8):1498-501. (PMID: 24894842)
ISME J. 2021 Jun;15(6):1858-1861. (PMID: 33619352)
Nat Methods. 2017 Dec;14(12):1156-1158. (PMID: 28945703)
J Mass Spectrom. 2014 Mar;49(3):223-32. (PMID: 24619548)
J Chem Ecol. 2013 Jul;39(7):1045-54. (PMID: 23881443)
ACS Chem Neurosci. 2013 Jul 17;4(7):1049-56. (PMID: 23607816)
Chem Commun (Camb). 2016 Aug 14;52(63):9801-4. (PMID: 27419250)
Anal Chem. 2015 May 19;87(10):5294-301. (PMID: 25914940)
BMC Syst Biol. 2008 Aug 12;2:74. (PMID: 18700030)
Int J Mass Spectrom. 2008 Dec 1;278(2-3):143-149. (PMID: 19956342)
Annu Rev Anal Chem (Palo Alto Calif). 2016 Jun 12;9(1):365-85. (PMID: 27070182)
J Mass Spectrom. 2000 Jan;35(1):1-12. (PMID: 10633229)
J Chromatogr A. 2021 Aug 16;1651:462302. (PMID: 34119720)
Phytochemistry. 2015 May;113:140-8. (PMID: 25457488)
Pest Manag Sci. 2019 Mar;75(3):607-615. (PMID: 30393944)
Front Microbiol. 2017 Nov 14;8:2192. (PMID: 29184541)
Food Chem. 2021 Dec 15;365:130399. (PMID: 34218107)
Anal Chem. 2014 May 6;86(9):4431-8. (PMID: 24712753)
J Am Soc Mass Spectrom. 2020 Mar 4;31(3):479-487. (PMID: 31971797)
Plant Physiol. 2021 Apr 23;185(4):1847-1859. (PMID: 33793933)
Microbiol Res. 2016 Jan;182:31-9. (PMID: 26686611)
Appl Microbiol Biotechnol. 2018 Oct;102(19):8493-8500. (PMID: 30033498)
J Am Chem Soc. 2018 Sep 12;140(36):11416-11423. (PMID: 30089208)
Biochem Biophys Res Commun. 2020 Jun 30;527(3):689-695. (PMID: 32423807)
Glycobiology. 2009 Sep;19(9):950-7. (PMID: 19542524)
Front Endocrinol (Lausanne). 2017 Apr 04;8:60. (PMID: 28421037)
Mass Spectrom Rev. 2007 Jul-Aug;26(4):606-43. (PMID: 17471576)
Biochim Biophys Acta. 2012 May;1822(5):784-93. (PMID: 22001064)
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13811-6. (PMID: 22869730)
Insect Biochem Mol Biol. 2014 Sep;52:115-23. (PMID: 25017143)
J Neurochem. 2021 Jul;158(2):391-412. (PMID: 33704768)

198069 Norwegian Cancer Society

Keywords: MALDI MSI; imaging; lipidomics; metabolomics; microbiology; plants

0 (Peptides)

Date Created: 20211127 Date Completed: 20211220 Latest Revision: 20211220

20221213

PMC8623934

10.3390/ijms222212393

34830273