Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Aging* ; Cognition* ; Memory, Short-Term*; Corpus Striatum/*metabolism ; Dopamine/*metabolism ; Receptors, Dopamine D2/*metabolism; Aged ; Gray Matter/metabolism ; Humans ; Middle Aged ; White Matter/metabolism

Within-person, moment-to-moment, variability in behavior increases with advancing adult age, potentially reflecting the influence of reduced structural and neurochemical brain integrity, especially that of the dopaminergic system. We examined the role of dopamine D2 receptor (D2DR) availability, grey-, and white-matter integrity, for between-person differences in cognitive variability in a large sample of healthy older adults (n = 181; 64-68 years) from the Cognition, Brain, and Aging (COBRA) study. Intra-individual variability (IIV) in cognition was measured as across-trial variability in participants' response times for tasks assessing perceptual speed and working memory, as well as for a control task of motor speed. Across the whole sample, no associations of D2DR availability, or grey- and white-matter integrity, to IIV were observed. However, within-person variability in cognition was increased in two subgroups of individuals displaying low mean-level cognitive performance, one of which was characterized by low subcortical and cortical D2DR availability. In this latter group, fronto-striatal D2DR availability correlated negatively with within-person variability in cognition. This finding suggests that the influence of D2DR availability on cognitive variability may be more easily disclosed among individuals with low dopamine-system integrity, highlighting the benefits of large-scale studies for delineating heterogeneity in brain-behavior associations in older age.
(© 2021. The Author(s).)

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0 (DRD2 protein, human)
0 (Receptors, Dopamine D2)
VTD58H1Z2X (Dopamine)

Date Created: 20211027 Date Completed: 20220126 Latest Revision: 20230207

20240829

PMC8548594

10.1038/s41598-021-00106-y

34702857