Assessment of Low Bone Mineral Density in Untreated Patients with Takayasu's Arteritis.

Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Publication: 2024- : [Hoboken, NJ] : Wiley
Original Publication: New York, NY : Hindawi Pub. Co.

Bone Diseases, Metabolic/*pathology ; Cholesterol, HDL/*blood ; Cholesterol, LDL/*blood ; Inflammation/*pathology ; Lumbar Vertebrae/*pathology ; Takayasu Arteritis/*pathology ; Vitamin D/*analogs & derivatives; Adult ; Bone Diseases, Metabolic/diagnostic imaging ; Case-Control Studies ; Female ; Humans ; Inflammation/blood ; Lipid Metabolism ; Lumbar Vertebrae/diagnostic imaging ; Male ; Takayasu Arteritis/etiology ; Takayasu Arteritis/metabolism ; Vitamin D/blood

Chronic inflammation affects bone metabolism and accelerates bone loss. This study is aimed at analyzing the prevalence of low bone mineral density (LBMD) in patients with untreated Takayasu's arteritis (TA) and risk factors. Forty untreated TA patients were enrolled, including 38 premenopausal women and 2 men before 50 years old. The control group included 60 age- and gender-matched healthy persons. Bone mineral density (BMD) of lumbar vertebrae and hip in patients with TA and the control group was measured by the dual-energy X-ray method. Serum 25OHD and β -CTX were also measured. The lumbar BMD of TA patients (0.89 ± 0.11 g/cm ² ) was significantly lower than that of the healthy control (0.97 ± 0.11 g/cm ² ). The prevalence of LBMD at the lumbar spine (17.50%) was significantly higher than that of the control group (3.33%). However, there was no significant difference at the hip. The 25OHD of TA patients was lower than that of healthy controls, while the level of β -CTX was higher. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in patients with LBMD were higher than those in patients with normal BMD. According to univariate correlation analysis, there was a significant negative correlation between LDL-C and lumbar BMD. Binary logistic regression analysis showed that LDL-C was an important factor affecting the occurrence of LBMD in patients with TA (OR = 25.269, P = 0.02). Our result reveals bone loss in TA patients, which hints the relationship among inflammation, lipid metabolism, and bone metabolism.
Competing Interests: All authors declare that they have no competing interests, and all authors confirm its accuracy.
(Copyright © 2021 Lingfei Mo et al.)

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0 (Cholesterol, HDL)
0 (Cholesterol, LDL)
1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)

Date Created: 20211025 Date Completed: 20220208 Latest Revision: 20220208

20250114

PMC8528581

10.1155/2021/6489631

34692838