Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, 2011-

Anti-Obesity Agents/*therapeutic use ; Diabetes Mellitus/*drug therapy ; Energy Metabolism/*genetics ; Obesity/*drug therapy; Diabetes Mellitus/etiology ; Diabetes Mellitus/physiopathology ; Humans ; Obesity/complications ; Obesity/metabolism ; Obesity/physiopathology ; Risk Factors

Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.

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Keywords: anti-obesity drugs; diabetes mellitus; energy balance; obesity; obesity metabolism

0 (Anti-Obesity Agents)

Date Created: 20211023 Date Completed: 20220118 Latest Revision: 20240817

20240817

PMC8533625

10.3390/biom11101426

34680059