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Influence of hydrotrope on solubility and bioavailability of curcumin: its complex formation and solid-state characterization.

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  • المؤلفون: Zhao Y;Zhao Y; Wu T; Wu T; Li H; Li H; Duan Y; Duan Y; Li H; Li H; Yang W; Yang W
  • المصدر:
    Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2021 Sep; Vol. 47 (9), pp. 1392-1400. Date of Electronic Publication: 2021 Oct 27.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: New York, Dekker.
    • الموضوع:
      Curcumin*/chemistry; Animals ; Biological Availability ; Calorimetry, Differential Scanning ; Powders ; Rats ; Solubility ; X-Ray Diffraction
    • نبذة مختصرة :
      In this study, meglumine (Meg) and arginine (Arg), acting as the hydrotrope, were used to form the stable curcumin (Cur)-hydrotrope complexes, respectively. Based on the single factor experiment optimization, the Cur-Meg/or Cur-Arg complex was prepared and then characterized by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), and differential scanning calorimetry (DSC). The results showed that Cur-Meg/Arg complexes bound together by hydrogen bonds/or ionic bonds were successfully prepared and the amorphous state of Cur appeared in their complexes. Compared with the Cur-Meg complex, Cur-Arg had better stability in stress testing. Cur-Meg/Arg complexes had a faster drug release rate in vitro and the area-under-curve (AUC) of Cur-Meg/Arg solutions in rats were at least 6.3-fold larger than that of the Cur suspensions. These findings suggest that hydrotropy combined with solid dispersion technique is a simple and effective way to improve the bioavailability of Cur.HIGHLIGHTSThe optimal Cur-Meg/or Cur-Arg complex powder was prepared and characterized.The Cur release rate in vitro was significantly improved.The bioavailability can be improved when using Cur-Meg/or Cur-Arg complex.A simple and effective way to improve the bioavailability of Cur.
    • Contributed Indexing:
      Keywords: Hydrotropy technique; arginine; bioavailability; complex; curcumin; meglumine
    • الرقم المعرف:
      0 (Powders)
      IT942ZTH98 (Curcumin)
    • الموضوع:
      Date Created: 20211020 Date Completed: 20220426 Latest Revision: 20220426
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1080/03639045.2021.1994987
    • الرقم المعرف:
      34668822