The relationship between high-density lipoprotein cholesterol (HDL-C) and glycosylated hemoglobin in diabetic patients aged 20 or above: a cross-sectional study.

Publisher: BioMed Central Country of Publication: England NLM ID: 101088676 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6823 (Electronic) Linking ISSN: 14726823 NLM ISO Abbreviation: BMC Endocr Disord Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Cholesterol, HDL/*blood ; Diabetes Mellitus/*blood ; Glycated Hemoglobin/*metabolism; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; China/epidemiology ; Cholesterol, HDL/analysis ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology ; Female ; Glycated Hemoglobin/analysis ; Humans ; Incidence ; Male ; Middle Aged ; Nutrition Surveys ; Young Adult

Aim: The incidence rate of diabetes is increasing year by year, seriously threatening human health. As a predictor of glycemic control, glycated hemoglobin is reported to be related to various complications and prognoses of diabetes. Besides, HDL-C dyslipidemia is a component of metabolic syndrome and may be related to various cardiovascular and cerebrovascular diseases. The principal objective of this project was to investigate the relationship between HDL-C and glycosylated hemoglobin in adult diabetic patients.
Methods: A total of 3171 adult diabetic patients aged 20 years and above were included in the present study from the National Health and Nutrition Examination Survey (NHANES). HDL-C and glycosylated hemoglobin were regarded as independent and dependent variables, respectively. EmpowerStats software and R (version 3.4.3) were used to examine the association between HDL-C and glycosylated hemoglobin.
Results: HDL-C was inversely associated with glycohemoglobin after adjusting for other covariates (β = - 0.004, 95% CI:- 0.008 to - 0.000, p = 0.044). Race/ethnicity and age were considered the most prominent interactive factors that affect the relationship between HDL and glycosylated hemoglobin by the interaction analysis. A U-shaped association was detected between HDL-C and glycosylated hemoglobin for people of other race/ethnicity or aged 60 and above, which had an inflection point of HDL-C at 60 mg/dL. In contrast, we observed an inverted U-shaped distribution between HDL-C and glycosylated hemoglobin in people under 40 with point of inflection located at 60 mg/dL as well.
Conclusions: HDL-C in diabetic patients is inversely associated with glycosylated hemoglobin and may be relevant to glycemic control. However, a U-shaped relationship was also observed in a certain kind of people, which implied that, though HDL-C is considered as metabolism and anti-atherogenic property, for diabetics, it is not the higher, the better.
(© 2021. The Author(s).)

Diabetes Care. 2013 Nov;36(11):3759-65. (PMID: 23877989)
Diabetes Care. 2017 Apr;40(4):529-537. (PMID: 28122840)
Vital Health Stat 1. 2013 Aug;(56):1-37. (PMID: 25078429)
Int J Mol Sci. 2021 May 06;22(9):. (PMID: 34066314)
Vasc Health Risk Manag. 2013;9:617-70. (PMID: 24174878)
JHEP Rep. 2020 Aug 15;2(6):100171. (PMID: 32964202)
Diabetes Care. 2013 Jan;36(1):176-8. (PMID: 23264289)
Metabolism. 2020 Sep 4;112:154351. (PMID: 32891675)
Front Endocrinol (Lausanne). 2019 Oct 02;10:651. (PMID: 31632344)
Rheum Dis Clin North Am. 2018 May;44(2):215-265. (PMID: 29622293)
Diabetes Metab Syndr Obes. 2020 Mar 11;13:679-691. (PMID: 32210601)
Trends Mol Med. 2020 Dec;26(12):1086-1100. (PMID: 32861590)
Clin Lab. 2020 Sep 1;66(9):. (PMID: 32902228)
Clin Sci (Lond). 2019 Nov 15;133(21):2221-2235. (PMID: 31722013)
Br J Clin Pharmacol. 2021 Jan;87(1):9-11. (PMID: 32864750)
J Cardiothorac Surg. 2017 Mar 31;12(1):21. (PMID: 28363280)
J Diabetes Res. 2016;2016:5342304. (PMID: 26989697)
Diabetes Care. 2020 Feb;43(2):426-432. (PMID: 31727686)
JCI Insight. 2020 Jan 16;5(1):. (PMID: 31830004)
PLoS Med. 2020 May 7;17(5):e1003094. (PMID: 32379755)
Cardiovasc Diabetol. 2020 Oct 13;19(1):176. (PMID: 33050931)
JAMA. 2015 Sep 22-29;314(12):1280-1. (PMID: 26393851)
Int J Mol Sci. 2020 Jan 17;21(2):. (PMID: 31963445)
JAMA Intern Med. 2015 Mar;175(3):356-62. (PMID: 25581565)
J Orthop Surg Res. 2021 Mar 15;16(1):190. (PMID: 33722260)
Pathology. 2019 Feb;51(2):142-147. (PMID: 30612759)
Am J Cardiol. 2021 May 1;146:8-14. (PMID: 33535058)
Stroke. 2019 Feb;50(2):291-297. (PMID: 30626289)
Lancet. 2014 Aug 16;384(9943):618-625. (PMID: 25131981)
N Engl J Med. 2014 Dec 18;371(25):2383-93. (PMID: 25404125)
J Clin Endocrinol Metab. 2019 Nov 1;104(11):5633-5641. (PMID: 31408161)
Nat Rev Cardiol. 2016 Jan;13(1):48-60. (PMID: 26323267)
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1874-1883. (PMID: 31315436)
Nat Rev Cardiol. 2021 Apr;18(4):291-304. (PMID: 33188304)
Diabetol Metab Syndr. 2014 Nov 06;6(1):119. (PMID: 25400701)
Nutrients. 2019 Aug 15;11(8):. (PMID: 31443226)

Keywords: Diabetes; Glycosylated hemoglobin; HDL-C; High-density lipoprotein cholesterol

0 (Blood Glucose)
0 (Cholesterol, HDL)
0 (Glycated Hemoglobin A)

Date Created: 20211012 Date Completed: 20220203 Latest Revision: 20221207

20250114

PMC8507179

10.1186/s12902-021-00863-x

34635098