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Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Biomarkers* ; Glucans*/chemistry ; Magnetite Nanoparticles*/chemistry; Asialoglycoprotein Receptor/*metabolism ; Liver Cirrhosis/*diagnosis ; Liver Cirrhosis/*metabolism ; Magnetic Resonance Imaging/*methods ; Optical Imaging/*methods; Animals ; Biocompatible Materials ; Cell Line, Tumor ; Cell Survival ; Chemical Phenomena ; Chemistry Techniques, Synthetic ; Ferric Compounds/chemistry ; Liver Cirrhosis/etiology ; Liver Cirrhosis/therapy ; Male ; Molecular Probes/chemical synthesis ; Molecular Probes/chemistry ; Molecular Targeted Therapy/methods ; Rats ; Reactive Oxygen Species
    • نبذة مختصرة :
      Early diagnosis and therapy of liver fibrosis is of utmost importance, especially considering the increased incidence of alcoholic and non-alcoholic liver syndromes. In this work, a systematic study is reported to develop a dual function and biocompatible nanoprobe for liver specific diagnostic and therapeutic applications. A polysaccharide polymer, pullulan stabilized iron oxide nanoparticle (P-SPIONs) enabled high liver specificity via asialogycoprotein receptor mediation. Longitudinal and transverse magnetic relaxation rates of 2.15 and 146.91 mM -1  s -1 respectively and a size of 12 nm, confirmed the T 2 weighted magnetic resonance imaging (MRI) efficacy of P-SPIONs. A current of 400A on 5 mg/ml of P-SPIONs raised the temperature above 50 °C, to facilitate effective hyperthermia. Finally, a NIR dye conjugation facilitated targeted dual imaging in liver fibrosis models, in vivo, with favourable histopathological results and recommends its use in early stage diagnosis using MRI and optical imaging, and subsequent therapy using hyperthermia.
      (© 2021. The Author(s).)
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    • الرقم المعرف:
      0 (Asialoglycoprotein Receptor)
      0 (Biocompatible Materials)
      0 (Biomarkers)
      0 (Ferric Compounds)
      0 (Glucans)
      0 (Magnetite Nanoparticles)
      0 (Molecular Probes)
      0 (Reactive Oxygen Species)
      1K09F3G675 (ferric oxide)
      8ZQ0AYU1TT (pullulan)
    • الموضوع:
      Date Created: 20210916 Date Completed: 20211210 Latest Revision: 20211214
    • الموضوع:
      20240628
    • الرقم المعرف:
      PMC8443657
    • الرقم المعرف:
      10.1038/s41598-021-97808-0
    • الرقم المعرف:
      34526590