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Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection.

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  • معلومة اضافية
    • المصدر:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101256509 Publication Model: Print Cited Medium: Internet ISSN: 1875-8592 (Electronic) Linking ISSN: 15740153 NLM ISO Abbreviation: Cancer Biomark Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Amsterdam ; Washington, DC : IOS Press, c2005-
    • الموضوع:
      Central Nervous System Neoplasms*/surgery ; Neutrophils*/pathology; Child ; Humans ; Kaplan-Meier Estimate ; Lymphocytes/pathology ; Prognosis ; Retrospective Studies
    • نبذة مختصرة :
      Background: Changes in neutrophil to lymphocyte ratio (ΔNLR) have been used as a clinical tool for stratification and prognosis of patients with solid tumors, there is scarce evidence of their clinical relevance in patients with tumors of the central nervous system who have also undergone surgical resection.
      Objective: Determine if (ΔNLR) are associated with poor response to treatment and worse prognosis in pediatric patients with central nervous system tumors (CNST) who underwent surgical resection.
      Methods: We performed a retrospective cohort study; demographic, clinical, and hematological variables were evaluated, Kaplan-Meier survival curves and Cox proportional hazards regression model were performed to evaluate prognosis.
      Results: The ΔNLR cutoff value obtained through the third interquartile range was 4.30; The probability of survival and complete response to treatment was different between patients with high ΔNLR when compared to patients with low ΔNLR (p= 0.013, p=≪ 0.001, respectively). A high ΔNLR behaved as an independent predictor of worse Overall Survival (HR 2,297; 95% CI: 1,075-4.908, p= 0.032).
      Conclusion: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.
    • Contributed Indexing:
      Keywords: Central nervous system tumors; neutrophil-to-lymphocyte ratio; pediatric; prognostic factor; survival; tumor resection
    • الموضوع:
      Date Created: 20210913 Date Completed: 20220419 Latest Revision: 20220419
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.3233/CBM-200857
    • الرقم المعرف:
      34511483