A Biological Insight into the Susceptibility to Influenza Infection in Junior Rats by Comprehensive Analysis of lncRNA Profiles.

Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Original Publication: New York, NY : Hindawi Pub. Co.

Influenza A virus/*pathogenicity ; MicroRNAs/*genetics ; Orthomyxoviridae Infections/*genetics ; RNA, Long Noncoding/*genetics ; RNA, Messenger/*genetics; Animals ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression Profiling ; Influenza A virus/isolation & purification ; Interleukin-17/genetics ; Interleukin-17/immunology ; MicroRNAs/immunology ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/pathology ; Orthomyxoviridae Infections/virology ; RNA, Long Noncoding/immunology ; RNA, Messenger/immunology ; Rats ; Rats, Sprague-Dawley

Long noncoding RNAs (lncRNAs) have been reported to participate in regulating many biological processes, including immune response to influenza A virus (IAV). However, the association between lncRNA expression profiles and influenza infection susceptibility has not been well elucidated. Here, we analyzed the expression profiles of lncRNAs, miRNAs, and mRNAs among IAV-infected adult rat (IAR), normal adult rat (AR), IAV-infected junior rat (IJR), and normal junior rat (JR) by RNA sequencing. Compared with differently expressed lncRNAs (DElncRNAs) between AR and IAR, 24 specific DElncRNAs were found between IJR and JR. Then, based on the fold changes and P value, the top 5 DElncRNAs, including 3 upregulated and 2 downregulated lncRNAs, were chosen to establish a ceRNA network for further disclosing their regulatory mechanisms. To visualize the differentially expressed genes in the ceRNA network, GO and KEGG pathway analysis was performed to further explore their roles in influenza infection of junior rats. The results showed that the downregulated DElncRNA-target genes were mostly enriched in the IL-17 signaling pathway. It indicated that the downregulated lncRNAs conferred the susceptibility of junior rats to IAV via mediating the IL-17 signaling pathway.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2021 Fen-Sheng Qiu et al.)

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0 (Il17a protein, rat)
0 (Interleukin-17)
0 (MicroRNAs)
0 (RNA, Long Noncoding)
0 (RNA, Messenger)

Date Created: 20210827 Date Completed: 20210922 Latest Revision: 20210922

20240628

PMC8384544

10.1155/2021/8112783

34447853