Experimental Evidence for Therapeutic Potentials of Propolis.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Anti-Anxiety Agents/*pharmacology ; Antineoplastic Agents/*pharmacology ; Antioxidants/*pharmacology ; Propolis/*pharmacology; Animals ; Brazil ; Caffeic Acids/pharmacology ; Humans ; New Zealand ; Phenylethyl Alcohol/analogs & derivatives ; Phenylethyl Alcohol/pharmacology ; Phenylpropionates/pharmacology

Propolis is produced by honeybees from materials collected from plants they visit. It is a resinous material having mixtures of wax and bee enzymes. Propolis is also known as bee glue and used by bees as a building material in their hives, for blocking holes and cracks, repairing the combs and strengthening their thin borders. It has been extensively used since ancient times for different purposes in traditional human healthcare practices. The quality and composition of propolis depend on its geographic location, climatic zone and local flora. The New Zealand and Brazilian green propolis are the two main kinds that have been extensively studied in recent years. Their bioactive components have been found to possess a variety of therapeutic potentials. It was found that Brazilian green propolis improves the cognitive functions of mild cognitive impairments in patients living at high altitude and protects them from neurodegenerative damage through its antioxidant properties. It possesses artepillin C (ARC) as the key component, also known to possess anticancer potential. The New Zealand propolis contains caffeic acid phenethyl ester (CAPE) as the main bioactive with multiple therapeutic potentials. Our lab performed in vitro and in vivo assays on the extracts prepared from New Zealand and Brazilian propolis and their active ingredients. We provided experimental evidence that these extracts possess anticancer, antistress and hypoxia-modulating activities. Furthermore, their conjugation with γCD proved to be more effective. In the present review, we portray the experimental evidence showing that propolis has the potential to be a candidate drug for different ailments and improve the quality of life.

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Keywords: artepillin C (ARC); biomedical properties; caffeic acid phenethyl ester (CAPE); honeybee; natural drug; propolis; traditional healthcare

0 (Anti-Anxiety Agents)
0 (Antineoplastic Agents)
0 (Antioxidants)
0 (Caffeic Acids)
0 (Phenylpropionates)
72944-19-5 (artepillin C)
9009-62-5 (Propolis)
G960R9S5SK (caffeic acid phenethyl ester)
ML9LGA7468 (Phenylethyl Alcohol)

Date Created: 20210827 Date Completed: 20210915 Latest Revision: 20240814

20240814

PMC8397973

10.3390/nu13082528

34444688