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Development of a standardized MRI protocol for pancreas assessment in humans.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Magnetic Resonance Imaging/*methods ; Magnetic Resonance Imaging/*standards ; Pancreas/*diagnostic imaging; Adult ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Healthy Volunteers ; Humans ; Image Processing, Computer-Assisted ; Male ; Phantoms, Imaging ; Prospective Studies ; Reproducibility of Results
    • نبذة مختصرة :
      Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Calibrated phantoms with known MRI properties were imaged at five sites with differing MRI hardware and software to develop a harmonized MRI imaging protocol. Subsequently, five healthy volunteers underwent MRI at four sites using the harmonized protocol to assess pancreas size, shape, apparent diffusion coefficient (ADC), longitudinal relaxation time (T1), magnetization transfer ratio (MTR), and pancreas and hepatic fat fraction. Following harmonization, pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time were reproducible, with coefficients of variation less than 10%. In contrast, non-standardized image processing led to greater variation in MRI measurements. By using a standardized MRI image acquisition and processing protocol, quantitative MRI of the pancreas performed at multiple locations can be incorporated into clinical trials comparing pancreas imaging measures and metabolic state in individuals with type 1 or type 2 diabetes.
      Competing Interests: The authors have declared that no competing interests exist.
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    • Grant Information:
      P30 DK020595 United States DK NIDDK NIH HHS; UL1 TR000445 United States TR NCATS NIH HHS; K12 DK094712 United States DK NIDDK NIH HHS
    • الموضوع:
      Date Created: 20210824 Date Completed: 20211215 Latest Revision: 20211221
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC8384163
    • الرقم المعرف:
      10.1371/journal.pone.0256029
    • الرقم المعرف:
      34428220