Longitudinal changes in the inferior cerebellar peduncle and lower limb motor recovery following subcortical infarction.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968555 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2377 (Electronic) Linking ISSN: 14712377 NLM ISO Abbreviation: BMC Neurol Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Cerebellum/*diagnostic imaging ; Cerebral Infarction/*diagnostic imaging ; Diffusion Tensor Imaging/*methods ; Lower Extremity/*diagnostic imaging ; Stroke/*diagnostic imaging; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Recovery of Function

Background: The cerebellum receives afferent signals from spinocerebellar pathways regulating lower limb movements. However, the longitudinal changes in the spinocerebellar pathway in the early stage of unilateral supratentorial stroke and their potential clinical significance have received little attention.
Methods: Diffusion tensor imaging and Fugl-Meyer assessment of lower limb were performed 1, 4, and 12 weeks after onset in 33 patients with acute subcortical infarction involving the supratentorial areas, and in 33 healthy subjects. We evaluated group differences in diffusion metrics in the bilateral inferior cerebellar peduncle (ICP) and analyzed the correlation between ICP diffusion metrics and changes to the Fugl-Meyer scores of the affected lower limb within 12 weeks after stroke.
Results: Significantly decreased fractional anisotropy and increased mean diffusivity were found in the contralesional ICP at week 12 after stroke compared to controls (all P < 0.01) and those at week 1 (all P < 0.05). There were significant fractional anisotropy decreases in the ipsilesional ICP at week 4 (P = 0.008) and week 12 (P = 0.004) compared to controls. Both fractional anisotropy (r s = 0.416, P = 0.025) and mean diffusivity (r s = -0.507, P = 0.005) changes in the contralesional ICP correlated with changes in Fugl-Meyer scores of the affected lower limb in all patients.
Conclusions: Bilateral ICP degeneration occurs in the early phase of supratentorial stroke, and diffusion metric values of the contralesional ICP are useful indicators of affected lower limb function after supratentorial stroke.
(© 2021. The Author(s).)

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2017YFC1307500 National Key R&D Program of China; 81600998 National Natural Science Foundation of China; 81571107, 81771137, 81971103 National Natural Science Foundation of China; 2016A030310132 Natural Science Foundation of Guangdong Province; 2021A1515010600 Natural Science Foundation of Guangdong Province; 2018B030340001 Key-Area Research and Development Program of Guangdong Province; 2018001 Sun Yat-sen University Clinical Research 5010 Program; 2019A030317006 Scientific and Technical Project of Guangdong Province; 2015B050501003, 2020A0505020004 Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases; Guangdong Provincial Engineering Center For Major Neurological Disease Treatment Guangdong Provincial Engineering Center For Major Neurological Disease Treatment; Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease; 2020B1111170002 Guangdong Provincial Clinical Research Center for Neurological Diseases; 2020B1212060017 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Keywords: Diffusion tensor imaging; Fugl-Meyer; Inferior cerebellar peduncle; Lower limb; Subcortical infarction

Date Created: 20210818 Date Completed: 20210825 Latest Revision: 20210825

20221213

PMC8369783

10.1186/s12883-021-02346-x

34404371