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Competing risk of mortality in association studies of non-fatal events.

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  • المؤلفون: Buzkova P;Buzkova P
  • المصدر:
    PloS one [PLoS One] 2021 Aug 13; Vol. 16 (8), pp. e0255313. Date of Electronic Publication: 2021 Aug 13 (Print Publication: 2021).
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Proportional Hazards Models*; Humans ; Aged ; Male ; Female ; Aged, 80 and over ; Mortality/trends ; Risk Factors ; Incidence
    • نبذة مختصرة :
      In geriatric research of non-fatal events, participants often die during the study follow-up without having the non-fatal event of interest. Cause-specific (CS) hazard regression and Fine-Gray (FG) subdistribution hazard regression are the two most common estimation approaches addressing such competing risk. We explain how the conventional CS approach and the FG approach differ and why many FG estimates of associations are counter-intuitive. Additionally, we clarify the indirect link between models for hazard and models for cumulative incidence. The methodologies are contrasted on data from the Cardiovascular Health Study, a population-based study in adults aged 65 years and older.
      Competing Interests: The authors have declared that no competing interests exist.
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    • Grant Information:
      U01 HL080295 United States HL NHLBI NIH HHS; U01 HL130114 United States HL NHLBI NIH HHS; HHSN268200800007C United States HL NHLBI NIH HHS; N01HC55222 United States HL NHLBI NIH HHS; N01HC85086 United States HL NHLBI NIH HHS; N01HC85082 United States HL NHLBI NIH HHS; N01HC85083 United States HL NHLBI NIH HHS; N01HC85080 United States HL NHLBI NIH HHS; N01HC85081 United States HL NHLBI NIH HHS; HHSN268201200036C United States HL NHLBI NIH HHS; HHSN268201800001C United States HL NHLBI NIH HHS; N01HC85079 United States HL NHLBI NIH HHS; R01 AG023629 United States AG NIA NIH HHS
    • الموضوع:
      Date Created: 20210813 Date Completed: 20240724 Latest Revision: 20240724
    • الموضوع:
      20240726
    • الرقم المعرف:
      PMC8362942
    • الرقم المعرف:
      10.1371/journal.pone.0255313
    • الرقم المعرف:
      34388170