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Associations between the thyroid panel and serum protein concentrations across pregnancy.
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- معلومة اضافية
- المصدر:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : Nature Publishing Group, copyright 2011-
- الموضوع:
- نبذة مختصرة :
Establishing any characteristic associations between the serum parameters of thyroid function and serum proteins in pregnancy may aid in elucidating the role of the thyroid gland in the regulation of pregnancy-specific metabolic processes and in selecting candidate biomarkers for use in their clinical assessment. Concentrations of thyroid stimulating hormone (TSH), free tri-iodothyronine (fT3) and free thyroxine (fT4), six electrophoretically separated protein fractions (albumin, alpha-1-, alpha2-, beta-1-, beta-2- and gamma-globulins), representative proteins-albumin (ALB), transferrin (TRF), alpha-2-macroglobulin (AMG) and ceruloplasmin (CER) were measured in 136 serum samples from 65 women in their consecutive trimesters of pregnancy. The concentrations of TSH, fT4 and fT3 were significantly correlated (p < 0.05) with the concentrations of the albumin, alpha-2- and beta-1 globulin fractions. Significant correlations (p < 0.05) which were positive between fT4 and ALB and negative between fT4 and TRF were established throughout pregnancy. Significant negative correlations (p < 0.05) were demonstrated for fT3 with alpha-2-globulin, AMG and CER. Changes in the serum concentrations of thyroid hormones seen between the trimesters were found to correlate with the concentrations of high-abundance serum proteins. Opposite directions of correlations between fT4 and ALB and fT4 and TRF observed throughout pregnancy may indicate the shared biological role of these parameters in maintaining maternal homeostasis and they suggest their potential use in the clinic as a simple biomarker panel. A negative correlation of fT3 with CER in the second trimester possibly reflects their involvement in the active regulation of metabolic processes.
(© 2021. The Author(s).)
- References:
Dan Med Bull. 1993 Sep;40(4):409-46. (PMID: 7693397)
Br J Obstet Gynaecol. 1983 Feb;90(2):139-45. (PMID: 6600623)
Am Fam Physician. 2005 Jan 1;71(1):105-12. (PMID: 15663032)
Sci Rep. 2018 Apr 26;8(1):6571. (PMID: 29700318)
J Endocrinol. 2003 Dec;179(3):367-77. (PMID: 14656206)
Clin Chem. 2015 May;61(5):704-13. (PMID: 25829408)
Gastroenterol Rep (Oxf). 2016 Nov;4(4):272-280. (PMID: 27174435)
J Clin Diagn Res. 2016 Jun;10(6):CC05-7. (PMID: 27504281)
J Obstet Gynaecol Res. 2010 Dec;36(6):1165-73. (PMID: 21040199)
BMC Endocr Disord. 2019 Jun 7;19(1):58. (PMID: 31174521)
Oxid Med Cell Longev. 2013;2013:218145. (PMID: 24386502)
Int J Endocrinol. 2015;2015:204893. (PMID: 26697065)
Digestion. 2009;79(4):203-10. (PMID: 19365122)
Dev Comp Immunol. 2017 Feb;67:300-309. (PMID: 27623236)
J Chromatogr A. 2007 Jun 15;1153(1-2):259-76. (PMID: 17166507)
Physiol Rev. 2014 Apr;94(2):355-82. (PMID: 24692351)
Int J Mol Sci. 2018 Jan 01;19(1):. (PMID: 29301248)
Mymensingh Med J. 2015 Jul;24(3):464-6. (PMID: 26329940)
Sci Rep. 2017 Jan 24;7:41302. (PMID: 28117377)
Mediators Inflamm. 2016;2016:6757154. (PMID: 27051079)
BMC Med. 2016 Sep 30;14(1):150. (PMID: 27686165)
J Clin Endocrinol Metab. 2016 Nov;101(11):4237-4243. (PMID: 27583471)
J Clin Endocrinol Metab. 2018 Jul 1;103(7):2447-2456. (PMID: 29889229)
Medicine (Baltimore). 2016 Jan;95(2):e2383. (PMID: 26765415)
PLoS One. 2011 May 04;6(5):e19603. (PMID: 21573190)
Mol Cell Endocrinol. 2005 Dec 21;245(1-2):60-6. (PMID: 16297527)
- الرقم المعرف:
0 (Blood Proteins)
0 (Serum Albumin)
0 (Serum Globulins)
0 (Thyroid Hormones)
06LU7C9H1V (Triiodothyronine)
9002-71-5 (Thyrotropin)
Q51BO43MG4 (Thyroxine)
- الموضوع:
Date Created: 20210806 Date Completed: 20211108 Latest Revision: 20211108
- الموضوع:
20231215
- الرقم المعرف:
PMC8342432
- الرقم المعرف:
10.1038/s41598-021-94358-3
- الرقم المعرف:
34354103
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